S
Shengwen Huang
Researcher at Boston University
Publications - 3
Citations - 21
Shengwen Huang is an academic researcher from Boston University. The author has contributed to research in topics: Haplotype & Single-nucleotide polymorphism. The author has an hindex of 2, co-authored 3 publications receiving 15 citations.
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Journal ArticleDOI
A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.
Vinod Vathipadiekal,John J. Farrell,Shuai Wang,Heather L. Edward,Heather Shappell,Abdullah M. Al-Rubaish,Fahad Al-Muhanna,Zaki A. Naserullah,Ahmed M. Al-Suliman,Hatem O. Qutub,Irene Simkin,Lindsay A. Farrer,Zhihua Jiang,Hong-Yuan Luo,Shengwen Huang,Gustavo Mostoslavsky,George J. Murphy,P.K. Patra,David H.K. Chui,Abdulrahman Alsultan,Amein K. Al-Ali,Paola Sebastiani,Martin H. Steinberg +22 more
TL;DR: An intronic single nucleotide polymorphism in ANTXR1, an anthrax toxin receptor (chromosome 2p13), contributes to the variation in HbF in Saudi AI haplotype sickle cell anemia and is the first gene in trans to HBB that is associated with HBF only in carriers of the SaudiAI haplotype.
Journal ArticleDOI
The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β(0) -thalassaemia homozygotes.
Zhihua Jiang,Hong-Yuan Luo,Shengwen Huang,John J. Farrell,Lance Davis,Roger Théberge,Katherine A. Benson,Suchada Riolueang,Vip Viprakasit,Nasir A. S. Al-Allawi,Sule Unal,Fatma Gumruk,Nejat Akar,A. Nazli Basak,Leonor Osorio,Catherine Badens,Serge Pissard,Philippe Joly,Andrew D. Campbell,Patrick G. Gallagher,Martin H. Steinberg,Bernard G. Forget,David H.K. Chui +22 more
TL;DR: Two 21‐year old dizygotic twin men of Iraqi descent were homozygous for HBB codon 8, deletion of two nucleotides (–AA) frame‐shift β0‐thalassaemia mutation (FSC8; HBB:c25_26delAA) and the inheritance of homozygosity for HMIP 3‐bp deletion at rs66650371 and heterozygosity in the twins and not found in any of the other 22 patients.
Journal ArticleDOI
A Candidate Trans-Acting Modulator of Fetal Hemoglobin Gene Expression in the Arab-Indian Haplotype of Sickle Cell Anemia
Vinod Vathipadiekal,John J. Farrell,Zhang Shuai,Heather L. Edward,Heather Shappell,Abdullah M. Al-Rubaish,Fahad Al-Muhanna,Zaki A. Naserullah,Ahmed M. Al-Suliman,Irene Simkin,Lindsay A. Farrer,Zhihua Jiang,Hong-Yuan Luo,Shengwen Huang,Gustavo Mostoslavsky,George J. Murphy,P.K. Patra,David H.K. Chui,Abdulrahman Alsultan,Amein K. Al-Ali,Paola Sebastiani,Martin H. Steinberg +21 more
TL;DR: In the Arab-Indian (AI) β-globin gene (HBB) haplotype of sickle cell anemia, fetal hemoglobin (HbF) levels are higher and the disease phenotype milder than in African HBB haplotypes, and 2 SNPs, rs4527238 and rs35685045 are associated with high HbF.