Z
Zhenghui Liu
Researcher at Peking Union Medical College
Publications - 17
Citations - 372
Zhenghui Liu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Innate immune system & TLR3. The author has an hindex of 11, co-authored 17 publications receiving 290 citations. Previous affiliations of Zhenghui Liu include Anschutz Medical Campus & University of Alabama at Birmingham.
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Journal ArticleDOI
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
Fang Zhang,Mary C. Gannon,Yunjia Chen,Shun Yan,Sixue Zhang,Wendy Feng,Jiahui Tao,Bingdong Sha,Zhenghui Liu,Takashi Saito,Takaomi C. Saido,C. Dirk Keene,Kai Jiao,Erik D. Roberson,Huaxi Xu,Qin Wang +15 more
TL;DR: A previously unappreciated direct role of norepinephrine signaling is revealed in connecting β-amyloid and tau, two key pathological components of AD pathogenesis, which provides translational insights into mechanisms underlying Aβ proteotoxicity.
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Cutting Edge: Foxp1 Controls Naive CD8+ T Cell Quiescence by Simultaneously Repressing Key Pathways in Cellular Metabolism and Cell Cycle Progression
Hairong Wei,Jianlin Geng,Bi Shi,Zhenghui Liu,Yin Hu Wang,Anna Stevens,Stephanie L. Sprout,Min Yao,Haikun Wang,Hui Hu +9 more
TL;DR: It is reported that the deletion of Foxp1 in naive CD8+ T cells leads to enhanced activation of the PI3K/Akt/mammalian target of rapamycin signaling pathway and its downstream cell growth and metabolism targets in response to IL-7.
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Breakdown of immune homeostasis in the testis of mice lacking Tyro3, Axl and Mer receptor tyrosine kinases
Yue Zhang,Nan Li,Qiaoyuan Chen,Keqin Yan,Zhenghui Liu,Xiaoyan Zhang,Peng Liu,Yongmei Chen,Daishu Han +8 more
TL;DR: It is demonstrated that the testicular immune homeostasis was impaired in TAM−/− mice, and major inflammatory cytokines were upregulated in the testis of TAM−/, and predominantly located in Sertoli cells (SCs).
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RIG-I-like receptors mediate innate antiviral response in mouse testis.
Weiwei Zhu,Qiaoyuan Chen,Keqin Yan,Zhenghui Liu,Nan Li,Xiaoyan Zhang,Lili Yu,Yongmei Chen,Daishu Han +8 more
TL;DR: It is demonstrated that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate the testicular innate antiviral response.
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Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells
TL;DR: It is demonstrated that adipose cells are equipped with innate antiviral system, which may modulate the function of adipocytes, as well as major virus sensors including Toll‐like receptor 3, melanoma differentiation‐associated antigen 5 and retinoic acid‐inducible gene I.