Z
Zhengpeng Wan
Researcher at Massachusetts Institute of Technology
Publications - 33
Citations - 779
Zhengpeng Wan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: B-cell receptor & B cell. The author has an hindex of 12, co-authored 26 publications receiving 508 citations. Previous affiliations of Zhengpeng Wan include Chinese Ministry of Education & Tsinghua University.
Papers
More filters
Journal ArticleDOI
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature
TL;DR: In this article, the authors review recent advancements in vascularizing organoids and engineering in vitro capillary beds, and further explore strategies to integrate them on a microfluidic based platform, aiming for establishing perfused vasculature throughout organoids in vitro.
Journal ArticleDOI
B Cell Activation Is Regulated by the Stiffness Properties of the Substrate Presenting the Antigens
Zhengpeng Wan,Shaosen Zhang,Yilin Fan,Kai Liu,Feng Du,Angel M. Davey,Huiyuan Zhang,Weidong Han,Chunyang Xiong,Wanli Liu +9 more
TL;DR: It is found that the mechanosensing ability of B cells is dependent on microtubules, and only mildly linked to the actin cytoskeleton, and the importance of the mechanical properties mediated by substrate stiffness in B cell activation is suggested.
Journal ArticleDOI
The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold
Zhengpeng Wan,Xiang-Jun Chen,Haodong Chen,Qinghua Ji,Yingjia Chen,Jing Wang,Yiyun Cao,Fei Wang,Jizhong Lou,Zhuo Tang,Wanli Liu +10 more
TL;DR: The mechanical force sensitivity and threshold that are required to activate different isotyped BCRs are defined and it is found that the cytoplasmic tail of the IgG-BCR heavy chain is both required and sufficient to account for the low mechanical force threshold.
Journal ArticleDOI
Substrate stiffness regulates B‐cell activation, proliferation, class switch, and T‐cell‐independent antibody responses in vivo
Yingyue Zeng,Junyang Yi,Zhengpeng Wan,Kai Liu,Ping Song,Alicia Chau,Fei Wang,Zai Chang,Weidong Han,Wenjie Zheng,Ying-Hua Chen,Chunyang Xiong,Wanli Liu +12 more
TL;DR: Substrate stiffness regulates B‐cell activation, proliferation, class switch, and T cell independent antibody responses in vivo, suggesting its broad application in manipulating the fate of B cells in vitro and in vivo.
Journal ArticleDOI
The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors
Wanli Liu,Wanli Liu,Elizabeth Chen,Xing Wang Zhao,Zhengpeng Wan,Yi Ren Gao,Angel M. Davey,Eric Huang,Lijia Zhang,Jillian Crocetti,Gabriel J. Sandoval,M. Gordon Joyce,Carrie Miceli,Jan Lukszo,L. Aravind,Wojciech Swat,Joseph Brzostowski,Susan K. Pierce +17 more
TL;DR: Increased B cell memory responses are encoded, in part, by a mechanism that involves SAP97 serving as a scaffolding protein in the IgG BCR immunological synapse, enabling BCR clustering and enhanced signaling.