Susan K. Pierce

TL;DR: Findings establish chronic active BCR signalling as a new pathogenetic mechanism in ABC DLBCL, suggesting several therapeutic strategies.

TL;DR: Research into the molecular basis of the spatial segregation and organization of signaling receptors provided by rafts is adding fundamentally to the understanding of the initiation and prolongation of signals in the immune system.

TL;DR: It is shown that upon cross-linking, the BCR rapidly translocates into ganglioside GM1-enriched lipid rafts that contain the Src family kinase Lyn and exclude the phosphatase CD45R, which provides evidence for a role for lipid rafting in the initial steps of BCR signaling and antigen targeting.

TL;DR: A protein microarray was developed and used to probe plasma from 220 individuals in Mali and provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features, which could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf.

TL;DR: Evidence is provided that a phenotypically similar atypical MBC population is significantly expanded in Pf-exposed Malian adults and children as young as 2 years of age as compared with healthy U.S. adult controls.