Z
Zhi Hong Wang
Researcher at University of Pennsylvania
Publications - 6
Citations - 1169
Zhi Hong Wang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Desmoglein & Desmoglein 3. The author has an hindex of 6, co-authored 6 publications receiving 1114 citations.
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Journal ArticleDOI
Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
My G. Mahoney,My G. Mahoney,Zhi Hong Wang,Kyle Rothenberger,Peter Koch,Peter Koch,Masayuki Amagai,John R. Stanley +7 more
TL;DR: It is suggested that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and it is demonstrated that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.
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Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1
TL;DR: It is shown here that exfoliative toxin A cleaved mouse and human Dsg1, but not closely related cadherins such as Dsg3.
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Desmoglein Isoform Distribution Affects Stratum Corneum Structure and Function
Peter M. Elias,Norihisa Matsuyoshi,Hong Wu,Chenyan Lin,Zhi Hong Wang,Barbara E. Brown,John R. Stanley +6 more
TL;DR: It is demonstrated that differential expression of desmoglein isoforms affects the major function of epidermis, the permeability barrier, by altering the structure of the stratum corneum.
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Protection against pemphigus foliaceus by desmoglein 3 in neonates.
Hong Wu,Zhi Hong Wang,Albert C. Yan,Stephen Lyle,Steven Fakharzadeh,James K. Wahl,Margaret J. Wheelock,Hiroyasu Ishikawa,Jouni Uitto,Masayuki Amagai,John R. Stanley +10 more
TL;DR: It has been proposed that in patients with pemphigus foliaceus the antibodies interfere with the adhesive function of desmoglein 1 and that blisters occur only in the superficial.
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Pemphigus Vulgaris and Pemphigus Foliaceus Antibodies are Pathogenic in Plasminogen Activator Knockout Mice
TL;DR: It is definitively demonstrated that plasminogen activator is not necessary for pemphigus immunoglobulin G to induce acantholysis in the neonatal mouse model of pemPHigus.