Z
Zhibing Weng
Researcher at Jiangnan University
Publications - 3
Citations - 42
Zhibing Weng is an academic researcher from Jiangnan University. The author has contributed to research in topics: Trastuzumab & Pertuzumab. The author has an hindex of 2, co-authored 3 publications receiving 22 citations.
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Journal ArticleDOI
A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action
Xuesai Zhang,Chen Jianhe,Zhibing Weng,Li Qingrou,Le Zhao,Ning Yu,Lan Deng,Wei Xu,Yan Yang,Zhu Zhenping,Haomin Huang +10 more
TL;DR: A new anti-HER2 humanized monoclonal antibody, 19H6-Hu, which binds to HER2 extracellular domain (ECD) with high affinity and inhibits proliferation of multiple HER2-overexpressing cancer cell lines as a single agent or in combination with trastuzumab.
Journal ArticleDOI
Reduction of charge variants by CHO cell culture process optimization.
TL;DR: Results of this study demonstrated that the concentration of Zn 2+ , duration of culturing, and temperature affect charge variants of a given mAb, and under the optimum conditions of 3L bioreactors, the most significant was thatZn 2 + and temperature shift could further improve the quality of antibody.
Journal ArticleDOI
Appearance and Formation Analysis of Multimers in High Concentration Antibodies
Zhibing Weng,Haomin Huang,Sixing Yang,Jian Ding,Zhiyong Wang,Minxia Huan,Xuesai Zhang,Zhao Jie,Xiao Jianguo,Li Zhao,Jian Jin,Zhu Zhenping,Huazhong Li +12 more
TL;DR: In this paper, the authors found that the high concentration antibody solution with rich multimers has a deeper color, which was confirmed by SEC-HPLC, DLS, and SEC-DLS methods.