Z
Zhihua Chen
Researcher at Shanghai Jiao Tong University
Publications - 264
Citations - 7795
Zhihua Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Vortex & Inflammation. The author has an hindex of 37, co-authored 242 publications receiving 4623 citations. Previous affiliations of Zhihua Chen include Guangzhou Medical University & Nanjing University of Science and Technology.
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CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents
TL;DR: This study reports that a short duration of CDK1 inhibition triggers a replication-associated DNA damage response (DDR) that is associated with a disruption of replication fork progression and leads to genome instability, and suggests that the therapeutic targetingCDK1 may be a novel approach for combination chemotherapy.
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Optimization of the aerodynamic configuration of a tubular projectile based on blind Kriging
TL;DR: The numerical optimal method proposed in this paper for optimizing the tubular projectile can provide important guidances for the aerodynamic configuration design of projectiles.
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Oleandrin induces DNA damage responses in cancer cells by suppressing the expression of Rad51.
Zhengqiang Bao,Bao-ping Tian,Xiaohui Wang,Hanrong Feng,Ye Liang,Zhihua Chen,Wen Li,Huahao Shen,Songmin Ying +8 more
TL;DR: It is found that oleandrin was effective to induce apoptosis in cancer cells, and cause rapid DNA damage response, represented by nuclear RPA (Replication Protein A, a single strand DNA binding protein) and γH2AX(a marker for DNA double strand breaks) foci formation.
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A reference system of smart manufacturing talent education (SMTE) in China
TL;DR: A reference system of SMTE in China is presented, which includes discipline system, training system, practice system, and assessment system, which has its reference value for the improvement of China’s smart manufacturing system architecture.
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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Zhehua Shao,Yangxia Tan,Qingya Shen,Li Hou,Bingpeng Yao,Jiao Qin,Peiyu Xu,C. Miao,Li-Nan Chen,Huibing Zhang,Dan-Dan Shen,Chao Zhang,Wei-Jie Li,Xufei Du,Fei Li,Zhihua Chen,Yi Jiang,H. Eric Xu,Songmin Ying,Honglei Ma,Yan Zhang,Huahao Shen +21 more
TL;DR: In this article , the structure of the CCL2-CCR2-G-protein complex was analyzed using a cryo-electron microscopy (CEM) setup, which revealed that the hydrophobic and polar interactions are present between both two chemokine receptors and the Gα-protein.