Z
Zhikun Lin
Researcher at Dalian Medical University
Publications - 10
Citations - 106
Zhikun Lin is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 2, co-authored 5 publications receiving 43 citations.
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Journal ArticleDOI
Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability.
Zhikun Lin,Ruiping He,Haifeng Luo,Chang Lu,Zhen Ning,Yuanhang Wu,Chuanchun Han,Guang Tan,Zhongyu Wang +8 more
TL;DR: The data reveal that the miR-185-ITGB5-β-catenin pathway plays an important role in HCC tumorigenesis, and ITGB5 may be a promising specific target for HCC therapy.
Journal ArticleDOI
Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells.
Zhikun Lin,Jia Liu,Guo-Qiang Jiang,Guang Tan,Peng Gong,Haifeng Luo,Hui-Min Li,Jian Du,Zhen Ning,Yi Xin,Zhongyu Wang +10 more
TL;DR: The results suggest that osthole may have potential chemotherapeutic activity against HCC, and this study investigated the anticancer activity of osthole using HCC cell lines.
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USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
Zhen Ning,Xin Guo,Xiaolong Liu,Chang Lu,Aman Wang,Xiaolin Wang,Wen Wang,Huan Chen,Wangshu Qin,Xinyu Liu,Lina Zhou,Chi Ma,Jian Du,Zhikun Lin,Haifeng Luo,Wuxiyar Otkur,Huan Qi,Di Chen,Tian Xia,Jiwei Liu,Guang Tan,Guowang Xu,Hai-long Piao +22 more
TL;DR: In this article , the ubiquitin-specific protease 22 (USP22) was identified as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPARγ) through K48-linked deUBiquitination, and in turn this stabilization increases acetyl-CoA carboxylase (ACC) and ATP citrate lyase (ACLY) expressions.
Journal ArticleDOI
Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats.
TL;DR: In this paper, the probiotic mixture significantly attenuated kaolin consumption, inflammation, oxidative stress, and the increase in 5-HT concentrations in rats with cisplatin-induced intestinal mucositis and pica.
Journal ArticleDOI
Metabolic Reprogramming and Risk Stratification of Hepatocellular Carcinoma Studied by Using Gas Chromatography–Mass Spectrometry-Based Metabolomics
Chengnan Fang,Hui Wang,Zhikun Lin,Xinyu Liu,Li-Wei Dong,Tian-Yi Jiang,Yexiong Tan,Zhen Ning,Yaorui Ye,Guang Tan,Guowang Xu +10 more
TL;DR: Results demonstrated that the metabolic reprogramming of HCC was mainly characterized by highly active glycolysis, enhanced fatty acid metabolism and inhibited tricarboxylic acid cycle, which satisfied the energy and biomass demands for tumor initiation and progression, meanwhile reducing apoptosis by counteracting oxidative stress.