Wuxiyar Otkur

TL;DR: Consistently, cell apoptosis was augmented by siRNAs targeting Beclin 1 and Atg5, supporting the hypothesis that autophagy induced by silibinin plays a protective role against UVB-induced epidermal apoptosis.

TL;DR: Silibinin treatment simultaneously repressed the activation of ATM‐p53 and autophagy and thereby protected UVB‐irradiated L929 cells from apoptotic death, which synergistically promoted cell apoptosis.

TL;DR: In this article , the ubiquitin-specific protease 22 (USP22) was identified as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated receptor gamma (PPARγ) through K48-linked deUBiquitination, and in turn this stabilization increases acetyl-CoA carboxylase (ACC) and ATP citrate lyase (ACLY) expressions.

TL;DR: It is shown that type I collagen promotes cilia growth through repressing the HDAC-autophagy pathway that can be involved in the interaction between primary cilia and col I, and that col I positively regulated cilia Growth through inhibition of autophagy.

TL;DR: Silibinin treatment suppressed the IGF-1R-JNK/ERK pathways and thus protected the cells from UVB-induced apoptosis, and thus prevented cell death in A431 cells.