Z
Zhiwei Cao
Researcher at Tongji University
Publications - 119
Citations - 3325
Zhiwei Cao is an academic researcher from Tongji University. The author has contributed to research in topics: Epitope & Gene. The author has an hindex of 27, co-authored 110 publications receiving 2879 citations. Previous affiliations of Zhiwei Cao include Liaoning University of Traditional Chinese Medicine & Shanghai University.
Papers
More filters
Journal ArticleDOI
Advances in Exploration of Machine Learning Methods for Predicting Functional Class and Interaction Profiles of Proteins and Peptides Irrespective of Sequence Homology
Journal ArticleDOI
Finding the molecular scaffold of nuclear receptor inhibitors through high-throughput screening based on proteochemometric modelling
TL;DR: Proteochemometric modelling was introduced to analysis the bioactivity between chemical compounds and NR targets and the methods and molecular scaffolds proposed can not only help the screening of potential therapeutic NR-inhibitors but also able to guide the future NR-related drug discovery.
Journal ArticleDOI
In silico target-specific siRNA design based on domain transfer in heterogeneous data.
TL;DR: This study proposes for the first time that the enhancement of target specificity of siRNA design can be achieved computationally by domain transfer in heterogeneous data sources from different siRNA targets, and presents transfer learning based method, HEGS, for target-specific siRNA efficacy modeling and feature selection.
Journal ArticleDOI
The Transmission, Infection Prevention, and Control during the COVID-19 Pandemic in China: A Retrospective Study
TL;DR: It is found that most cases were limited to Hubei Province, especially in Wuhan, and the mortality rate was lower in non-Wuhan areas, and strong and effective IPC with strict implementation was able to effectively and quickly control the pandemic.
Journal ArticleDOI
Co-Expression of miR155 or LSD1 shRNA Increases the Anti-Tumor Functions of CD19 CAR-T Cells
Jing Zhang,Jingjing Zhu,Genhui Zheng,Qianyu Wang,Xiaorui Li,Yarui Feng,Fengqing Shang,Siyuan He,Q. Jiang,Bi-min Shi,Dong Wang,Zhiwei Cao,Jianxun Wang +12 more
TL;DR: A novel approach in which a microRNA (miRNA) or short-hairpin RNA (shRNA) cassette was integrated into CAR-expressing retroviral vectors and found that anti-CD19 CAR-T cells with miR155 upregulation or LSD1 downregulation exhibited increased anti-tumor functions in vitro and in vivo.