L
Lianyi Han
Researcher at Tencent
Publications - 75
Citations - 10027
Lianyi Han is an academic researcher from Tencent. The author has contributed to research in topics: PubChem & Protein function prediction. The author has an hindex of 32, co-authored 74 publications receiving 8302 citations. Previous affiliations of Lianyi Han include National Institutes of Health & National University of Singapore.
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Journal ArticleDOI
PubChem Substance and Compound databases
Sunghwan Kim,Paul A. Thiessen,Evan E Bolton,Jie Chen,Gang Fu,Asta Gindulyte,Lianyi Han,Jane He,Siqian He,Benjamin A. Shoemaker,Jiyao Wang,Bo Yu,Jian-Jian Zhang,Stephen H. Bryant +13 more
TL;DR: An overview of the PubChem Substance and Compound databases is provided, including data sources and contents, data organization, data submission using PubChem Upload, chemical structure standardization, web-based interfaces for textual and non-textual searches, and programmatic access.
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CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.
Aron Marchler-Bauer,Yu Bo,Lianyi Han,Jane He,Christopher J. Lanczycki,Shennan Lu,Farideh Chitsaz,Myra K. Derbyshire,Renata C. Geer,Noreen R. Gonzales,Marc Gwadz,David I. Hurwitz,Fu Lu,Gabriele H. Marchler,James S. Song,Narmada Thanki,Zhouxi Wang,Roxanne A. Yamashita,Dachuan Zhang,Chanjuan Zheng,Lewis Y. Geer,Stephen H. Bryant +21 more
TL;DR: NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints.
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The NCBI BioSystems database
Lewis Y. Geer,Aron Marchler-Bauer,Renata C. Geer,Lianyi Han,Jane He,Siqian He,Chunlei Liu,Wenyao Shi,Stephen H. Bryant +8 more
TL;DR: The NCBI BioSystems database centralizes and cross-links existing biological systems databases and allows users of NCBI’s Entrez databases to quickly categorize proteins, genes and small molecules by metabolic pathway, disease state or other BioSystem type.
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SVM-Prot: web-based support vector machine software for functional classification of a protein from its primary sequence
TL;DR: SVMProt shows a certain degree of capability for the classification of distantly related proteins and homologous proteins of different function and thus may be used as a protein function prediction tool that complements sequence alignment methods.
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PubChem's BioAssay Database
Yanli Wang,Jewen Xiao,Tugba O. Suzek,Jian Zhang,Jiyao Wang,Zhigang Zhou,Lianyi Han,Karen Karapetyan,Svetlana Dracheva,Benjamin A. Shoemaker,Evan E Bolton,Asta Gindulyte,Stephen H. Bryant +12 more
TL;DR: An update for the PubChem BioAssay resource is provided, including information content growth, data model extension and new developments of data submission, retrieval, analysis and download tools.