Z
Zhiyi Sun
Researcher at New England Biolabs
Publications - 47
Citations - 1815
Zhiyi Sun is an academic researcher from New England Biolabs. The author has contributed to research in topics: DNA & DNA methylation. The author has an hindex of 17, co-authored 40 publications receiving 1386 citations. Previous affiliations of Zhiyi Sun include Nanjing University & University of Massachusetts Amherst.
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Journal ArticleDOI
Structural bias in T4 RNA ligase-mediated 3′-adapter ligation
TL;DR: It is concluded that T4 RNA ligases do not show significant primary sequence preference in RNA substrates, but are biased against structural features within RNAs and adapters, and it is proposed that using randomized adapters may improve RNA representation in experiments that include a 3′-adapter ligation step.
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Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
Peter W. S. Hill,Harry G. Leitch,Cristina E. Requena,Zhiyi Sun,Rachel Amouroux,Monica Roman-Trufero,Malgorzata Borkowska,Jolyon Terragni,Romualdas Vaisvila,Sarah Linnett,Hakan Bagci,Hakan Bagci,Gopuraja Dharmalingham,Vanja Haberle,Vanja Haberle,Boris Lenhard,Yu Zheng,Sriharsa Pradhan,Petra Hajkova +18 more
TL;DR: This work uncovers a fundamental biological role for gonadal germline reprogramming and identifies the epigenetic principles of the PGC-to-gonocyte transition that will help to guide attempts to recapitulate complete gametogenesis in vitro.
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An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
Chen Zhu,Kaori Sakuishi,Sheng Xiao,Zhiyi Sun,Sarah Zaghouani,Guangxiang Gu,Chao Wang,Dewar J. Tan,Chuan Wu,Manu Rangachari,Thomas Pertel,Hyun-Tak Jin,Rafi Ahmed,Ana C. Anderson,Vijay K. Kuchroo +14 more
TL;DR: It is demonstrated that IL-27 induces NFIL3, which promotes permissive chromatin remodeling of the Tim-3 locus and induces Tim- 3 expression together with the immunosuppressive cytokine IL-10, and it is shown that theIL-27/NFIL3 signaling axis is crucial for the induction ofTim-3 in vivo.
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High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells
Zhiyi Sun,Jolyon Terragni,Janine G. Borgaro,Yiwei Liu,Ling Yu,Shengxi Guan,Hua Wang,Dapeng Sun,Xiaodong Cheng,Zhenyu Zhu,Sriharsa Pradhan,Yu Zheng +11 more
TL;DR: It is proposed that some amounts of transiently stable 5hmCs may indicate a poised epigenetic state or demethylation intermediate, whereas others may suggest a locally accessible chromosomal environment for the TET enzymatic apparatus.
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Bias in Ligation-Based Small RNA Sequencing Library Construction Is Determined by Adaptor and RNA Structure
TL;DR: This study investigates the effects of ligation bias by using a pool of randomized ligation substrates, defined mixtures of miRNA sequences and several combinations of adaptors in HTS library construction, and shows that like the 3’ adaptor ligation step, the 5’ adaptation is also biased.