Z
Zhiyuan Hu
Researcher at Chinese Academy of Sciences
Publications - 124
Citations - 5550
Zhiyuan Hu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drug delivery & Circulating tumor cell. The author has an hindex of 32, co-authored 114 publications receiving 4455 citations. Previous affiliations of Zhiyuan Hu include Center for Excellence in Education & Institute for Systems Biology.
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Journal ArticleDOI
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Kai Wang,Shile Zhang,Bruz Marzolf,Pamela Troisch,Amy Brightman,Zhiyuan Hu,Leroy Hood,David J. Galas +7 more
TL;DR: It is demonstrated that specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration, but their changes can be detected significantly earlier.
Journal ArticleDOI
Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm
Yeteng Zhong,Yeteng Zhong,Zhuoran Ma,Shoujun Zhu,Jingying Yue,Mingxi Zhang,Alexander L. Antaris,Jie Yuan,Ran Cui,Hao Wan,Ying Zhou,Weizhi Wang,Weizhi Wang,Ngan F. Huang,Jian Luo,Zhiyuan Hu,Zhiyuan Hu,Hongjie Dai +17 more
TL;DR: The authors synthesize rare earth down-converting nanocrystals as promising fluorescent probes for in vivo imaging in this spectral region with superior spatial resolution and tissue penetration depth, but few NIR-IIb probes exist.
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Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study.
Jianming Xu,Yun Zhang,Ru Jia,Chun Yan Yue,Lianpeng Chang,Rongrui Liu,Gairong Zhang,Chuan Hua Zhao,Yao Yue Zhang,Chun Xia Chen,Yan Wang,Xin Yi,Zhiyuan Hu,Jian Jun Zou,Quan Ren Wang +14 more
TL;DR: The RP2D for apatinib as combination therapy was 250 mg, which showed encouraging clinical activity in patients with advanced HCC, and demonstrated manageable toxicity at recommended single-agent doses of both drugs.
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Hypothalamic malonyl-CoA as a mediator of feeding behavior.
TL;DR: Evidence supporting the hypothesis that hypothalamic malonyl-CoA, a substrate of FAS, is an indicator of global energy status and mediates the feeding behavior of mice is provided.
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Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging.
Ling Zhu,Kun Wang,Cui Jian,Huan Liu,Xiangli Bu,Huailei Ma,Weizhi Wang,He Gong,Christopher Lausted,Leroy Hood,Guang Yang,Zhiyuan Hu +11 more
TL;DR: A real-time, label-free, and quantitative method to detect and characterize tumor-derived exosomes without enrichment or purification is presented and a positive correlation between the metastatic potential of tumor cell lines and exosome secretion is found.