Z
Zhuofan Lei
Researcher at Qingdao University
Publications - 7
Citations - 123
Zhuofan Lei is an academic researcher from Qingdao University. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 103 citations. Previous affiliations of Zhuofan Lei include Chinese Academy of Sciences.
Papers
More filters
Journal ArticleDOI
mGluR1,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice
TL;DR: In this article, the authors studied the characteristics of neural networks in basolateral amygdala and the influences of metabotropic glutamate receptor (mGluR) on their dynamics in DBA/2 mice showing anxiety-related genetic defects.
Journal ArticleDOI
Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals.
Dangui Wang,Jun Zhao,Zilong Gao,Na Chen,Bo Wen,Wei Lu,Zhuofan Lei,Changfeng Chen,Yahui Liu,Jing Feng,Jin-Hui Wang +10 more
TL;DR: This study studied the issue in the barrel cortex by in vivo two-photon calcium imaging, electrophysiology, and neural tracing in a mouse model that the simultaneous whisker and olfaction stimulations led to odorant-induced whisker motion and a cross-modal reflex arose.
Journal ArticleDOI
Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes
Zhuofan Lei,Dangui Wang,Na Chen,Ke Ma,Wei Lu,Wei Lu,Zhenhua Song,Shan Cui,Jin-Hui Wang,Jin-Hui Wang +9 more
TL;DR: The upregulated miRNA-324 in associative learning knocks down Ttbk1-mediated Tau phosphorylation and microtubule depolymerization, which drives the balance between polymerization and depolymersization toward the axon prolongation and spine stabilization to initiate new synapse innervations and to recruit associative memory cells.
Journal ArticleDOI
Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice
TL;DR: The data indicate that inhibition of autophagy after SCI potentiates pro-inflammatory activation in microglia and is associated with worse functional outcomes, while increasing autophagic with trehalose, decreased inflammation and improved outcomes.
Journal ArticleDOI
Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus.
TL;DR: It is suggested that reward‐induced positive memory relieves mouse anxiety‐related behavior by strengthening synaptic efficacy and PKC in the hippocampus, which imply the underlying cellular and molecular processes involved in the beneficial effects of psychological therapies treating anxiety disorders.