R
Rodney M. Ritzel
Researcher at University of Maryland, Baltimore
Publications - 51
Citations - 2694
Rodney M. Ritzel is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 20, co-authored 42 publications receiving 1705 citations. Previous affiliations of Rodney M. Ritzel include University of Connecticut Health Center & University of Connecticut.
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Journal Article
Microglia and ischemic stroke: a double-edged sword.
TL;DR: Fine-tuning immunomodulatory interventions based on the heterogeneous profiles of microglia are urgently needed for ischemic stroke.
Journal ArticleDOI
Functional differences between microglia and monocytes after ischemic stroke
Rodney M. Ritzel,Anita Patel,Jeremy M. Grenier,Joshua Crapser,Rajkumar Verma,Evan R. Jellison,Louise D. McCullough +6 more
TL;DR: The resident microglia population is vulnerable to the effects of severe ischemia, show compromised cell cycle progression, and adopt a largely pro-inflammatory phenotype after stroke, suggesting that the early wave of infiltrating monocytes may be beneficial to stroke repair.
Journal ArticleDOI
Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits.
Rebecca J. Henry,Rodney M. Ritzel,James P. Barrett,Sarah J. Doran,Yun Jiao,Jennie B. Leach,Gregory L. Szeto,Gregory L. Szeto,Junfang Wu,Bogdan A. Stoica,Bogdan A. Stoica,Alan I. Faden,David J. Loane,David J. Loane +13 more
TL;DR: It is shown that short-term elimination of microglia during the chronic phase of TBI followed by repopulation results in long-term improvements in neurological function, suppression of neuroinflammatory and oxidative stress pathways, and a reduction in persistent neurodegenerative processes.
Journal ArticleDOI
Old Maids: Aging and Its Impact on Microglia Function
TL;DR: The impact of normal aging on microglial function is outlined, the potential mechanisms underlying age-related changes in microglia are highlighted, and how aging can shape the recovery process following injury is discussed.
Journal ArticleDOI
Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury.
Rodney M. Ritzel,Joshua Crapser,Anita Patel,Rajkumer Verma,Jeremy M. Grenier,Anjali Chauhan,Evan R. Jellison,Louise D. McCullough +7 more
TL;DR: A novel population of resident memory, immunosurveillant CD8 T cells that represent a hallmark of CNS aging and appear to modify microglia homeostasis under normal conditions, but are primed to potentiate inflammation and leukocyte recruitment following ischemic injury is identified.