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Junyun He

Researcher at University of Maryland, Baltimore

Publications -  40
Citations -  1450

Junyun He is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 15, co-authored 34 publications receiving 1006 citations. Previous affiliations of Junyun He include Pennington Biomedical Research Center & Arizona State University.

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Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

TL;DR: Several vaccine antigens, including Norwalk virus capsid protein and hepatitis B core antigen, were expressed using the BeYDV vector at levels up to 1mg per g of leaf mass, and the protective mAb 6D8 against Ebola virus was produced.
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Sleep restriction impairs blood-brain barrier function.

TL;DR: It is proposed that changes of the BBB contribute to many pathophysiological processes in the brain of subjects with chronic sleep restriction (CSR), and that CSR compromises microvascular function.
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Robust production of virus‐like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

TL;DR: This study explored the use of lettuce, which grows quickly yet produces low levels of secondary metabolites and viral vector-based transient expression systems to develop a robust PMP production platform and establishes a new production platform for biological pharmaceutical agents that are effective, safe, low cost, and amenable to large-scale manufacturing.
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Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice.

TL;DR: Findings indicate that pharmacological microglia-deletion reduces neuroinflammation in the injured spinal cord and brain, improving recovery of cognition, depressive-like behavior, and motor function.