Z
Zhuying Xia
Researcher at Johns Hopkins University School of Medicine
Publications - 2
Citations - 602
Zhuying Xia is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Bone remodeling & Cathepsin K. The author has an hindex of 2, co-authored 2 publications receiving 411 citations.
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Journal ArticleDOI
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Hui Xie,Zhuang Cui,Long Wang,Zhuying Xia,Yin Hu,Lingling Xian,Changjun Li,Liang Xie,Janet L. Crane,Mei Wan,Gehua Zhen,Qin Bian,Bin Yu,Weizhong Chang,Tao Qiu,Maureen Pickarski,Le Thi Duong,Jolene J. Windle,Xiang-Hang Luo,Er-Yuan Liao,Xu Cao +20 more
TL;DR: Pharmacotherapies that increase PDGF-BB secretion from preosteoclasts offer a new therapeutic target for treating osteoporosis by promoting angiogenesis and thus bone formation.
Journal ArticleDOI
Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice.
TL;DR: It is demonstrated that cells in the primary and secondary spongiosa respond differently to glucocorticoids and genetic manipulation, and inhibition of osteoclast coupling factors, such as through inhibition of cathepsin K, may be a potential preventive treatment strategy against GIO in the growing skeleton.