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Weizhong Chang
Researcher at Johns Hopkins University School of Medicine
Publications - 2
Citations - 1280
Weizhong Chang is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Bone remodeling & Mesenchymal stem cell. The author has an hindex of 2, co-authored 2 publications receiving 934 citations. Previous affiliations of Weizhong Chang include Johns Hopkins University.
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Journal ArticleDOI
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
Gehua Zhen,Chunyi Wen,Chunyi Wen,Xiaofeng Jia,Yu Li,Janet L. Crane,Simon C. Mears,Frederic B. Askin,Frank J. Frassica,Weizhong Chang,Jie Yao,John A. Carrino,Andrew J. Cosgarea,Dmitri Artemov,Qianming Chen,Zhihe Zhao,Xuedong Zhou,Lee H. Riley,Paul D. Sponseller,Mei Wan,William W. Lu,William W. Lu,Xu Cao +22 more
TL;DR: It is shown that transforming growth factor β1 is activated in subchondral bone in response to altered mechanical loading in an anterior cruciate ligament transection mouse model of osteoarthritis, and inhibition of this process could be a potential therapeutic approach to treating this disease.
Journal ArticleDOI
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Hui Xie,Zhuang Cui,Long Wang,Zhuying Xia,Yin Hu,Lingling Xian,Changjun Li,Liang Xie,Janet L. Crane,Mei Wan,Gehua Zhen,Qin Bian,Bin Yu,Weizhong Chang,Tao Qiu,Maureen Pickarski,Le Thi Duong,Jolene J. Windle,Xiang-Hang Luo,Er-Yuan Liao,Xu Cao +20 more
TL;DR: Pharmacotherapies that increase PDGF-BB secretion from preosteoclasts offer a new therapeutic target for treating osteoporosis by promoting angiogenesis and thus bone formation.