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Xu Cao
Researcher at Johns Hopkins University School of Medicine
Publications - 76
Citations - 4145
Xu Cao is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Osteoarthritis & Bone remodeling. The author has an hindex of 27, co-authored 56 publications receiving 2755 citations. Previous affiliations of Xu Cao include Johns Hopkins University.
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Journal ArticleDOI
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Hui Xie,Zhuang Cui,Long Wang,Zhuying Xia,Yin Hu,Lingling Xian,Changjun Li,Liang Xie,Janet L. Crane,Mei Wan,Gehua Zhen,Qin Bian,Bin Yu,Weizhong Chang,Tao Qiu,Maureen Pickarski,Le Thi Duong,Jolene J. Windle,Xiang-Hang Luo,Er-Yuan Liao,Xu Cao +20 more
TL;DR: Pharmacotherapies that increase PDGF-BB secretion from preosteoclasts offer a new therapeutic target for treating osteoporosis by promoting angiogenesis and thus bone formation.
Journal ArticleDOI
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
Lingling Xian,Xiangwei Wu,Xiangwei Wu,Lijuan Pang,Lijuan Pang,Michael Lou,Clifford J. Rosen,Tao Qiu,Janet L. Crane,Frank J. Frassica,Liming Zhang,Juan Pablo Rodríguez,Xiaofeng Jia,Shoshana Yakar,Shouhong Xuan,Argiris Efstratiadis,Mei Wan,Xu Cao +17 more
TL;DR: It is reported that IGF-1 released from the bone matrix during bone remodeling stimulates osteoblastic differentiation of recruited mesenchymal stem cells by activation of mammalian target of rapamycin (mTOR), thus maintaining proper bone microarchitecture and mass.
Journal ArticleDOI
Transforming growth factor-β in stem cells and tissue homeostasis.
TL;DR: The ways in which temporal and spatial activation of transforming growth factor-β (TGF-β), a multi-functional signaling molecule, are needed for proper tissue development and regulation of stem cells throughout the body are reviewed.
Journal ArticleDOI
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells
Xu Cao,Xiangwei Wu,Xiangwei Wu,Deborah A. Frassica,Bing Yu,Lijuan Pang,Lijuan Pang,Lingling Xian,Mei Wan,Weiqi Lei,Michael Armour,Erik Tryggestad,John Wong,Chunyi Wen,William W. Lu,Frank J. Frassica +15 more
TL;DR: It is indicated that irradiation produces free radicals that adversely affect the survival of MSCs in both distal and proximal femora, and this injury to the vasculatures and the microenvironment affect the niches for stem cells during the recovery period.
Journal ArticleDOI
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Shouan Zhu,Jianxi Zhu,Jianxi Zhu,Gehua Zhen,Yihe Hu,Senbo An,Senbo An,Yusheng Li,Yusheng Li,Qin Zheng,Zhiyong Chen,Ya Yang,Mei Wan,Richard L. Skolasky,Yong Cao,Tianding Wu,Bo Gao,Mi Yang,Manman Gao,Julia S. Kuliwaba,Shuangfei Ni,Lei Wang,Chuanlong Wu,David M. Findlay,Holger K. Eltzschig,Hongwei Ouyang,Janet L. Crane,Feng Quan Zhou,Yun Guan,Xinzhong Dong,Xu Cao +30 more
TL;DR: Results suggest that intervention of the axonal guidance molecules (e.g., netrin-1) derived from aberrant subchondral bone remodeling may have therapeutic potential for OA pain.