Z
Zi-Wei Ye
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 36
Citations - 2978
Zi-Wei Ye is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Viral replication & Arabidopsis. The author has an hindex of 15, co-authored 36 publications receiving 2001 citations. Previous affiliations of Zi-Wei Ye include University of Hong Kong.
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Journal ArticleDOI
Zoonotic origins of human coronaviruses.
TL;DR: An overview of the existing knowledge about the seven HCoVs is presented, with a focus on the history of their discovery as well as their zoonotic origins and interspecies transmission, and the current CoV disease 2019 (COVID-19) epidemic is discussed.
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SARS-CoV-2 and COVID-19: The most important research questions
TL;DR: Nine most important research questions concerning virus transmission, asymPTomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis are highlighted.
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Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
Kam Leung Siu,Kit-San Yuen,Carlos Castaño-Rodríguez,Zi-Wei Ye,Man Lung Yeung,Sin Yee Fung,Shuofeng Yuan,Chi-Ping Chan,Kwok-Yung Yuen,Luis Enjuanes,Dong-Yan Jin +10 more
TL;DR: It is shown that the SARS‐CoV open reading frame 3a (ORF3a) accessory protein activates the NLRP3 inflammasome by promoting TNF receptor‐associated factor 3 (TRAF3)–mediated ubiquitination of apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC).
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A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses.
TL;DR: Current understanding of the induction of a proinflammatory cytokine storm by other highly pathogenic human coronaviruses, their adaptation to humans and their usurpation of the cell death programmes are summarized.
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SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Shuofeng Yuan,Hin Chu,Jasper Fuk-Woo Chan,Zi-Wei Ye,Lei Wen,Bingpeng Yan,Pok Man Lai,Kah Meng Tee,Jingjing Huang,Dongdong Chen,Cun Li,Xiaoyu Zhao,Dong Yang,Man Chun Chiu,Cyril C. Y. Yip,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Kong-Hung Sze,Jie Zhou,Ivy Hau-Yee Chan,Kin-Hang Kok,Kelvin K. W. To,Richard Y.T. Kao,Johnson Yiu-Nam Lau,Dong-Yan Jin,Stanley Perlman,Kwok-Yung Yuen +26 more
TL;DR: This study identifies a basic lipogenic transactivation event with broad relevance to human viral infections and represents SREBP as a potential target for the development of broad-spectrum antiviral strategies.