M
Man Chun Chiu
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 34
Citations - 1646
Man Chun Chiu is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Organoid & Medicine. The author has an hindex of 11, co-authored 25 publications receiving 1106 citations. Previous affiliations of Man Chun Chiu include University of Hong Kong.
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Journal ArticleDOI
Infection of bat and human intestinal organoids by SARS-CoV-2.
Jie Zhou,Cun Li,Xiaojuan Liu,Man Chun Chiu,Xiaoyu Zhao,Dong Wang,Yuxuan Wei,Andrew Chak-Yiu Lee,Anna Jinxia Zhang,Anna Jinxia Zhang,Hin Chu,Hin Chu,Jian Piao Cai,Cyril C. Y. Yip,Ivy Hau-Yee Chan,Kenneth K. Y. Wong,Owen Tak Yin Tsang,Kwok-Hung Chan,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Kelvin K. W. To,Kelvin K. W. To,Honglin Chen,Honglin Chen,Kwok-Yung Yuen,Kwok-Yung Yuen +25 more
TL;DR: Bat and human intestinal organoids can support replication of SARS-CoV-2, enabling further characterization of the virus lifecycle and investigation of potential mechanisms of enteric infection in COVID-19.
Journal ArticleDOI
Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Jie Zhou,Cun Li,Guangyu Zhao,Hin Chu,Dong Wang,Helen H.N. Yan,Vincent Kwok-Man Poon,Lei Wen,Bosco Ho-Yin Wong,Xiaoyu Zhao,Man Chun Chiu,Dong Yang,Yixin Wang,Rex Au-Yeung,Ivy Hau-Yee Chan,Shihui Sun,Jasper Fuk-Woo Chan,Kelvin K. W. To,Ziad A. Memish,Ziad A. Memish,Victor M. Corman,Christian Drosten,Ivan Hung,Yusen Zhou,Suet Yi Leung,Kwok-Yung Yuen +25 more
TL;DR: It is demonstrated that human primary intestinal epithelial cells, small intestine explants, and intestinal organoids were highly susceptible to MERS-CoV and can sustain robust viral replication and suggest that the human intestinal tract may serve as an alternative infection route for MERS -CoV.
Journal ArticleDOI
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Shuofeng Yuan,Hin Chu,Jasper Fuk-Woo Chan,Zi-Wei Ye,Lei Wen,Bingpeng Yan,Pok Man Lai,Kah Meng Tee,Jingjing Huang,Dongdong Chen,Cun Li,Xiaoyu Zhao,Dong Yang,Man Chun Chiu,Cyril C. Y. Yip,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Kong-Hung Sze,Jie Zhou,Ivy Hau-Yee Chan,Kin-Hang Kok,Kelvin K. W. To,Richard Y.T. Kao,Johnson Yiu-Nam Lau,Dong-Yan Jin,Stanley Perlman,Kwok-Yung Yuen +26 more
TL;DR: This study identifies a basic lipogenic transactivation event with broad relevance to human viral infections and represents SREBP as a potential target for the development of broad-spectrum antiviral strategies.
Journal ArticleDOI
Differentiated human airway organoids to assess infectivity of emerging influenza virus
Jie Zhou,Cun Li,Norman Sachs,Man Chun Chiu,Bosco Ho-Yin Wong,Hin Chu,Vincent Kwok-Man Poon,Dong Wang,Xiaoyu Zhao,Lei Wen,Wenjun Song,Wenjun Song,Shuofeng Yuan,Kenneth K. Y. Wong,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Hans Clevers,Kwok-Yung Yuen +18 more
TL;DR: The proximal differentiated airway organoids can be utilized to predict the infectivity of influenza viruses and, more broadly, provide a universal platform for studying the biology and pathology of the human airway.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Among Children
Chi-Wai Leung,Yat-wah Kwan,Po-wan Ko,Susan S. Chiu,Po-yee Loung,Nai-chung Fong,Lai-ping Lee,Yim-wo Hui,Helen K. W. Law,Wilfred Hing Sang Wong,Kwok-Hung Chan,J. S. Malik Peiris,Wilina Lim,Yu-Lung Lau,Man Chun Chiu +14 more
TL;DR: Sore throat and initial and peak neutrophilia seem to be predictors of severe illness, and the clinical case definition performed well in the epidemic.