Zsuzsanna Schelz

TL;DR: The interaction of peppermint oil and menthol with the antibiotics was studied on the same bacterial strain with the checkerboard method and a new mechanism of plasmid curing was established for one of the oil components.

TL;DR: A review of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure.

TL;DR: The role of quorum sensing is well known in microbial pathogenicity and antibiotic resistance, and the inhibition of QS signals reduces the problem of resistance and virulence.

TL;DR: Bacterial plasmids can be eliminated from bacterial species grown as pure or mixed bacterial cultures in the presence of sub-inhibitory concentrations of non-mutagenic heterocyclic compounds, and the inhibition of conjugational transfer of antibiotic resistance plasmid can be exploited to reduce the spread of antibiotic resistantplasmid in the ecosystem.

TL;DR: New derivatives of TZ were synthesised and their in vitro activity against a reference strain of M. tuberculosis was evaluated with the aid of the BACTEC 460 system and derivatives that presented significant activity were evaluated by ex vivo studies and were shown to enhance the killing of intracellular M.culosis.