Showing papers in "Cancer Letters in 2002"

TL;DR: The data support further preclinical studies of betulinic acid not confined to melanoma and neuroectodermal tumors independently of p53 status, and support the antineoplastic activity of this drug.

TL;DR: Therapeutic strategies targeting the oncogenic consequences of p21 expression may provide a new approach to chemoprevention and treatment of cancer.

TL;DR: It is suggested that esculetin can inhibit the growth of human leukemia HL-60 cells by G1 phase cell cycle arrest as a result of inhibited pRb phosphorylation.

TL;DR: BAG-family proteins participate in a wide variety of cellular processes including cell survival, proliferation, migration and apoptosis, and have been shown to have a supra-additive anti-apoptotic effect with Bcl-2.

TL;DR: It is shown that mild oxidative stress increases protein degradation in skeletal muscle by causing an increased expression of the major components of the ubiquitin-proteasome pathway.

TL;DR: The results suggest that CDX2 and CDX1 may play a role during IM formation and gastric carcinogenesis.

TL;DR: New evidence is presented that green tea and a cancer preventive drug, sulindac, have synergistic preventive effects and an approach to develop green tea capsules as a cancer preventives in the US is discussed, aiming at taking full advantage of this cancer preventive beverage.

TL;DR: Experimental results demonstrating an interaction of cadherins with tyrosine kinase receptors suggest that changes in cadherin expression may not only modulate tumour cell adhesion but also affect signal transduction and, hence, the malignant phenotype.

TL;DR: The results suggest that flavonoids are potent regulators of cyclin B and p21 for cell cycle progression, which may play some roles in prevention of carcinogenesis.

TL;DR: Different cellular mechanisms appear to be involved in the androgen-independent progression of PCa, including cytokine and growth factor-mediated activation of the AR as well as neuroendocrine differentiation.

TL;DR: The results are the first to demonstrate that physiologic levels of two CLA preparations, their constituent isomers, and the c9,t11-CLA elongation product, c11,t13-conjugated eicosadienoic acid, induce dose-dependent inhibitory effects on cancer proliferation in vitro.

TL;DR: Results indicate that while all four tea catechins inhibit the process of angiogenesis, EGCg alone can reduce the binding of VEGF to its receptors and thus affects the downstream signaling.

TL;DR: From the analysis of tumors at the cytogenetic and molecular level non-random genetic changes have been identified, including ploidy changes, amplification of the oncogene MYCN, deletion of chromosome 1p, gains of chromosome arm 17q, and deletions of 11q as well as of other genomic regions that allow tumors to be classified into subsets with distinct biological features and clinical behavior.

TL;DR: The results suggest that propofol inhibits the invasion ability of cancer cells by modulating Rho A and this agent might be an ideal anesthetic for cancer surgery.

TL;DR: All of the compounds tested showed inhibitory effects against EBV-EA activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter.

TL;DR: The results suggest that curcumin inhibits telomerase activity by down-regulating hTERT expression in breast cancer cells and this down-regulation is not through the c-myc pathway.

TL;DR: Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha).

TL;DR: It is shown that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude mice with established human breast tumors reduced tumor growth and metastasis and decreased extracellular levels of VEGF, which may be one mechanistic explanation to the decreased tumor growthand metastasis.

TL;DR: Caffeic acid phenethyl ester may exert its anti-inflammatory effect by inhibiting the iNOS gene expression at the transcriptional level through the suppression of NF-kappaB activation, and by directly inhibited the catalytic activity of iNos.

TL;DR: Both the lipids extracted from the germinating spores and the SBGS of G. lucidum had remarkable antitumor effects in a dose-dependent manner, and could significantly inhibit three tumors with an inhibition of 80-90%.

TL;DR: Evidence is provided that this p53 polymorphism is implicated in bladder carcinogenesis and that individuals harboring the Arg/Arg genotype have an increased risk of developing bladder cancer.

TL;DR: Four normal and 79 human prostate cancer specimens were examined, by immunohistochemistry, for expression of voltage-gated potassium ion channels, and strong immunostaining was observed in the normal and 47% of Pca specimens.

TL;DR: Observations indicate that polyamine metabolism might be an important target in the anti-proliferative effects of cocoa polyphenols.

TL;DR: It is suggested that the cancer-protective property of fruits, vegetables, and related products is partly conferred by the cumulative impact of volatile isoprenoid constituents.

TL;DR: It is suggested that AA induced apoptosis through increased intracellular Ca(2+), which, in turn, enhanced p53 expression in HepG2 cells, and further suggest that AA may be a valuable agent for the therapeutic intervention of human hepatomas.

TL;DR: The expression of IGFBP-3 was restored by the demethylating agent 5-aza-2'-deoxycytidine in HCC cell line with promoter hypermethylation (HepG2) and may be used as a therapeutic target for HCC.

TL;DR: Genistein down-regulates the transcription and translation of genes critically involved in the control of angiogenesis, tumor cell invasion and metastasis, suggesting the possible therapeutic role of genistein for metastatic prostate cancer.

TL;DR: Results would suggest that 6-NO(2)-7- OHC and 7,8-OHC might have a therapeutic role to play in the treatment of renal cell carcinoma.

TL;DR: A case-control study of two functional polymorphisms in MTHFR, dietary folate intake and breast cancer finds patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia.

TL;DR: Investigation of cisplatin-induced apoptosis and the effects on cell cycle-related proteins and cell cycle changes in hepatoma cell lines found it to be p53-dependent and p21(WAF1/CIP1) and Fas-dependent, respectively.