G
Gary K. Smith
Researcher at Research Triangle Park
Publications - 54
Citations - 2906
Gary K. Smith is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Tetrahydrobiopterin & In vivo. The author has an hindex of 28, co-authored 54 publications receiving 2809 citations. Previous affiliations of Gary K. Smith include Wellcome Trust.
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Journal ArticleDOI
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.
Journal ArticleDOI
Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase
Chiara Luberto,Daniel F. Hassler,Paola Signorelli,Yasuo Okamoto,Hirofumi Sawai,Eric E. Boros,Debra J. Hazen-Martin,Lina M. Obeid,Yusuf A. Hannun,Gary K. Smith +9 more
TL;DR: GW4869 was able, in a dose-dependent manner, to significantly protect from cell death as measured by nuclear condensation, caspase activation, PARP degradation, and trypan blue uptake, therefore localizing N-SMase activation upstream of mitochondrial dysfunction.
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A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal
TL;DR: A rapid, simple and sensitive assay has been developed for tyrosine-3-monooxygenase, the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis.
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Glucocorticoids Regulate Inducible Nitric Oxide Synthase by Inhibiting Tetrahydrobiopterin Synthesis and L-Arginine Transport
TL;DR: Glucocorticoids regulate NOx production following cytokine exposure in cardiac microvascular endothelial cells primarily by limiting BH4 and L-arginine availability.
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Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.
TL;DR: Results show how broad cross-profiling can provide important insights to assist kinase drug discovery with implications for biological target selection, the choice of tool compounds for target validation, and lead discovery and optimization.