Z
Zuomei Li
Researcher at University of California, Los Angeles
Publications - 4
Citations - 1230
Zuomei Li is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Tyrosine kinase & Bruton's tyrosine kinase. The author has an hindex of 4, co-authored 4 publications receiving 1212 citations.
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Journal ArticleDOI
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals
Andrew M. Scharenberg,Ousama El-Hillal,David A. Fruman,Laurie O. Beitz,Zuomei Li,Siqi Lin,Ivan Gout,Ivan Gout,Lewis C. Cantley,David J. Rawlings,Jean-Pierre Kinet +10 more
TL;DR: It is demonstrated that phosphatidylinositol‐3,4,5‐trisphosphate interacting with the PH domain acts as an upstream activation signal for Tec kinases, resulting in Tec kinase‐dependent phospholipase Cγ tyrosine phosphorylation and inositol trisph phosphate production.
Journal ArticleDOI
Btk/tec kinases regulate sustained increases in intracellular ca2+ following b-cell receptor activation
Anne Catherine Fluckiger,Zuomei Li,Roberta M. Kato,Matthew I. Wahl,Hans D. Ochs,Richard Longnecker,Jean-Pierre Kinet,Owen N. Witte,Andrew M. Scharenberg,David J. Rawlings +9 more
TL;DR: Results suggest that Btk maintains increased intracellular calcium levels by controlling a Tg‐sensitive, IP3‐gated calcium store(s) that regulates store‐operated calcium entry.
Journal ArticleDOI
Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases
TL;DR: Activation of Btk was dependent on the catalytic activity of all three enzymes and an intact Btk PH domain and SRC transphosphorylation site, defining Btk as a downstream target of PI 3-kinase-γ and Src family kinases.
Journal ArticleDOI
Btk function in B cell development and response
TL;DR: Mutations in Bruton's tyrosine kinase result in the B cell immunodeficiencies XLA in humans and Xid in mice, and both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor crosslinking depend on Btk.