Z
Zygmunt Kazimierczuk
Researcher at Warsaw University of Life Sciences
Publications - 131
Citations - 3305
Zygmunt Kazimierczuk is an academic researcher from Warsaw University of Life Sciences. The author has contributed to research in topics: Glycosylation & Benzimidazole. The author has an hindex of 27, co-authored 130 publications receiving 3114 citations. Previous affiliations of Zygmunt Kazimierczuk include Polish Academy of Sciences & University of Osnabrück.
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Journal Article
Synthesis and proapoptotic properties of new casein kinase II inhibitors.
Mirosława Koronkiewicz,Magda Zukowska,Zdzisław Chilmonczyk,Andrzej Orzeszko,Zygmunt Kazimierczuk +4 more
TL;DR: All the tested compounds induced apoptosis and cytostatic effects in the promyelocytic leukemia cell line (HL-60) and the proapoptotic effect was concentration and time dependent.
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In Search of the Antimicrobial Potential of Benzimidazole Derivatives.
Monika Janeczko,Zygmunt Kazimierczuk,Andrzej Orzeszko,Andrzej Niewiadomy,Ewa Król,Ryszard Szyszka,Maciej Masłyk +6 more
TL;DR: A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidAZol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi and only 8, 16, 18 and 19 showed moderate to good inhibition against bacterial strains.
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Effects of chlorination and deoxiribose substitution on electron density distribution in indazole molecule studied by 35Cl NQR spectroscopy and ab initio calculations
TL;DR: In this article, the influence of site of substitution and kind of substituent on the resonance frequency was analyzed and electron density distribution and electrostatic potential in the molecules were calculated by the B3LYP/6-31G ∗ method and the results were correlated with experimental data.
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Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study.
Tomasz Kryczka,Zygmunt Kazimierczuk,Mariola Kozłowska,Stanisław J. Chrapusta,Leena Vilpo,Juhani Vilpo,Krzysztof Stachnik,Monika Janisz,Paweł Grieb +8 more
TL;DR: Two 5′-O-esters of cladribine and its parental nucleoside 2′-deoxyadenosine with chlorambucil are synthesized and shows promise for clinical utility as a chlor Ambucil prodrug and thus warrants a more detailed study in vivo.
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Stereoselective synthesis of 2-azapurine 2'-deoxy-β-D-ribonucleosides by nucleobase-anion glycosylation
Zygmunt Kazimierczuk,Frank Seela +1 more
TL;DR: The distribution of regioisomers is as follows: N-9 (32%), N-2 (30%), and N-7 (7%) together with a minor amount of an unidentified labile glycosylation product.