J
Juhani Vilpo
Researcher at University of Tampere
Publications - 97
Citations - 3624
Juhani Vilpo is an academic researcher from University of Tampere. The author has contributed to research in topics: Chronic lymphocytic leukemia & DNA repair. The author has an hindex of 28, co-authored 97 publications receiving 3443 citations. Previous affiliations of Juhani Vilpo include University of Helsinki & Helsinki University Central Hospital.
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Journal ArticleDOI
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.
Abdelilah Aboussekhra,Maureen Biggerstaff,Mahmud K.K. Shivji,Juhani Vilpo,Vincent Moncollin,Vladimir N. Podust,Miroslava Protić,Ulrich Hübscher,Jean-Marc Egly,Richard D. Wood +9 more
TL;DR: Nucleotide excision repair is the principal way by which human cells remove UV damage from DNA by combining DNA polymerase epsilon, RFC, PCNA, and DNA ligase I with ERCC1- and XPF-correcting activity.
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Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope
Gerard Tobin,Ulf Thunberg,A. Johnson,Inger Eriksson,Ola Söderberg,Karin Karlsson,Mats Merup,Gunnar Juliusson,Juhani Vilpo,Gunilla Enblad,Christer Sundström,Göran Roos,Richard Rosenquist +12 more
TL;DR: These new findings strengthen the suggestion that VH3-21-using cases comprise a new CLL entity, irrespective of VH gene mutation status, and implicate that a common antigen epitope, perhaps of pathogenic significance, is recognized by the highly homologous VH 3-21/Vlambda2-14 Ig molecules expressed in individual tumors.
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Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia.
Gerard Tobin,Ulf Thunberg,Karin Karlsson,Fiona Murray,Anna Laurell,Kerstin Willander,Gunilla Enblad,Mats Merup,Juhani Vilpo,Gunnar Juliusson,Christer Sundström,Ola Söderberg,Göran Roos,Richard Rosenquist +13 more
TL;DR: Structurally similarHCDR3s associated with preferential V(L) gene usage implies selection of BCRs, especially in subsets showing high HCDR3 similarities, thus pointing to restricted antigen recognition sites and possibly involvement of specific antigens in CLL development.
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Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status.
Mia Thorsélius,Alexander Kröber,Fiona Murray,Ulf Thunberg,Gerard Tobin,Andreas Bühler,Dirk Kienle,Emilia Albesiano,Rossana Maffei,Lan-Phuong Dao-Ung,James S. Wiley,Juhani Vilpo,Anna Laurell,Mats Merup,Göran Roos,Karin Karlsson,Nicholas Chiorazzi,Roberto Marasca,Hartmut Döhner,Stephan Stilgenbauer,Richard Rosenquist +20 more
TL;DR: Highly restricted B-cell receptors and worse outcome characterize VH3-21+ CLLs independent of geographic origin and mutation status.
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Abnormal expression of apoptosis-related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma.
Bálint Nagy,Bálint Nagy,Tuija Lundán,Marcelo L. Larramendy,Marcelo L. Larramendy,Yan Aalto,Ying Zhu,Tarja Niini,Henrik Edgren,A. Ferrer,Juhani Vilpo,Erkki Elonen,Kim Vettenranta,Kaarle Franssila,Sakari Knuutila +14 more
TL;DR: MYC overexpression was significantly associated with shorter overall survival in MCL (P’< 0·01), and AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpressed than those with an abnormal karyotypes.