Center for Open Science

About: Center for Open Science is a nonprofit organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Replication (statistics) & Open science. The organization has 68 authors who have published 123 publications receiving 12899 citations. The organization is also known as: COS & cos.io.

Seeking the “holy grail” of biomarkers to improve stroke risk prediction of clinical scores

Abstract: Biomarkers are defined as “objective indications of medical state observed from outside the patient—which can be measured accurately and reproducibly.”1 Biomarkers have 3 major potential roles in clinical practice: (1) to help the patient understand their risk of disease, which could lead to direct improvement of quality of life; (2) to direct the patient to make lifestyle changes that could improve health, such as restricting or improving dietary choices, becoming more active, and adhering to a plan laid out in collaboration with their physician; and (3) to direct a medical professional to make a (better) clinical decision based on known risk factors or disease(s) associated with a specific biomarker(s).2 Given the complex pathophysiology of ischemic stroke, biomarkers that can stratify risk and identify those individuals most likely to have a cerebrovascular event are considered the “holy grail” of prognostic tools.