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Stephen R. Williams
Researcher at University of Virginia
Publications - 45
Citations - 3210
Stephen R. Williams is an academic researcher from University of Virginia. The author has contributed to research in topics: Population & Haploinsufficiency. The author has an hindex of 23, co-authored 45 publications receiving 2143 citations. Previous affiliations of Stephen R. Williams include Salk Institute for Biological Studies & Research Triangle Park.
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Journal ArticleDOI
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Hou-Feng Zheng,Vincenzo Forgetta,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Karol Estrada,Alberto Roselló-Díez,Paul Leo,Chitra Lekha Dahia,Chitra Lekha Dahia,Kyung-Hyun Park-Min,Jonathan H Tobias,Charles Kooperberg,Aaron Kleinman,Unnur Styrkarsdottir,Ching-Ti Liu,Charlotta Uggla,Daniel S. Evans,Carrie M. Nielson,Klaudia Walter,Ulrika Pettersson-Kymmer,Shane A. McCarthy,Joel Eriksson,Tony Kwan,Mila Jhamai,Katerina Trajanoska,Yasin Memari,J L Min,Jie Huang,Petr Danecek,Beth Wilmot,Rui Li,Wen-Chi Chou,Lauren E. Mokry,Alireza Moayyeri,Alireza Moayyeri,Melina Claussnitzer,Chia-Ho Cheng,Warren A. Cheung,Carolina Medina-Gomez,Bing Ge,Shu Huang Chen,Kwangbom Choi,Ling Oei,James Fraser,Robert Kraaij,Matthew A. Hibbs,Matthew A. Hibbs,Celia L Gregson,Denis Paquette,Albert Hofman,Carl Wibom,Gregory J. Tranah,Mhairi Marshall,Brooke Gardiner,Katie Cremin,Paul L. Auer,Li Hsu,Susan M. Ring,Joyce Y. Tung,Gudmar Thorleifsson,A.W. Enneman,Natasja M. van Schoor,Lisette C. P. G. M. de Groot,Nathalie van der Velde,Beatrice Melin,John P. Kemp,John P. Kemp,Claus Christiansen,Adrian Sayers,Yanhua Zhou,Sophie Calderari,Jeroen van Rooij,Christopher S. Carlson,Ulrike Peters,Soizik Berlivet,Josée Dostie,André G. Uitterlinden,Stephen R. Williams,Charles R. Farber,Daniel Grinberg,Andrea Z. LaCroix,Jeffrey Haessler,Daniel I. Chasman,Franco Giulianini,Lynda M. Rose,Paul M. Ridker,John A. Eisman,John A. Eisman,John A. Eisman,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Xavier Nogués,Natalia Garcia-Giralt,Lenore Launer,V. Gudnason,Dan Mellström,Liesbeth Vandenput,Najaf Amin,Cornelia M. van Duijn,Magnus Karlsson,Östen Ljunggren,Olle Svensson,Göran Hallmans,François Rousseau,Sylvie Giroux,Johanne Bussiere,Pascal P. Arp,Fjorda Koromani,Richard L. Prince,Richard L. Prince,Joshua R. Lewis,Joshua R. Lewis,Bente L. Langdahl,A. Pernille Hermann,Jens Erik Beck Jensen,Stephen Kaptoge,Kay-Tee Khaw,Jonathan Reeve,Jonathan Reeve,Melissa M. Formosa,Angela Xuereb-Anastasi,Kristina Åkesson,Fiona E. McGuigan,Gaurav Garg,José M. Olmos,María T. Zarrabeitia,José A. Riancho,Stuart H. Ralston,Nerea Alonso,Xi Jiang,David Goltzman,Tomi Pastinen,Elin Grundberg,Dominique Gauguier,Eric S. Orwoll,David Karasik,George Davey-Smith,Albert V. Smith,Kristin Siggeirsdottir,Tamara B. Harris,M. Carola Zillikens,Joyce B. J. van Meurs,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Matthew T. Maurano,Nicholas J. Timpson,Nicole Soranzo,Richard Durbin,Scott Wilson,Scott Wilson,Scott Wilson,Evangelia E. Ntzani,Evangelia E. Ntzani,Matthew A. Brown,Kari Stefansson,Kari Stefansson,David A. Hinds,Tim D. Spector,L. Adrienne Cupples,Claes Ohlsson,Celia M. T. Greenwood,Rebecca D. Jackson,David W. Rowe,Cynthia A. Loomis,David M. Evans,David M. Evans,Cheryl L. Ackert-Bicknell,Alexandra L. Joyner,Emma L. Duncan,Emma L. Duncan,Douglas P. Kiel,Fernando Rivadeneira,J. Brent Richards,J. Brent Richards +174 more
TL;DR: Evidence is provided that low‐frequency non‐coding variants have large effects on BMD and fracture, thereby providing rationale for whole‐genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
Journal ArticleDOI
Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems
Stephen R. Williams,Micheala A. Aldred,Vazken M. Der Kaloustian,Vazken M. Der Kaloustian,Fahed Halal,Gordon C. Gowans,D. Ross McLeod,Sara Zondag,Helga V. Toriello,R. Ellen Magenis,Sarah H. Elsea +10 more
TL;DR: Data presented here show that deletion or mutation of HDAC4 results in reduced expression of RAI1, which causes Smith-Magenis syndrome when haploinsufficient, providing a link to the overlapping findings in these disorders.
Journal ArticleDOI
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.
Kristen R. Maynard,Leonardo Collado-Torres,Lukas M. Weber,Cedric Uytingco,Brianna K. Barry,Stephen R. Williams,Joseph L. Catallini,Matthew N. Tran,Zachary Besich,Madhavi Tippani,Jennifer Chew,Yifeng Yin,Joel E. Kleinman,Thomas M. Hyde,Nikhil Rao,Stephanie C. Hicks,Keri Martinowich,Andrew E. Jaffe +17 more
TL;DR: This article used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex and identified extensive layer-enriched expression signatures and refined associations to previous laminar markers.
Journal ArticleDOI
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Symen Ligthart,Ahmad Vaez,Urmo Võsa,Maria G. Stathopoulou,P. De Vries,Bram P. Prins,P. J. van der Most,Toshiko Tanaka,Elnaz Naderi,Lynda M. Rose,Ying Wu,Robert Karlsson,Maja Barbalić,Honghuang Lin,René Pool,Gu Zhu,Aurélien Macé,C Sidore,Stella Trompet,Massimo Mangino,Maria Sabater-Lleal,John P. Kemp,Ali Abbasi,Tim Kacprowski,Niek Verweij,Albert V. Smith,Tao Huang,Carola Marzi,Mary F. Feitosa,Kurt Lohman,Marcus E. Kleber,Yuri Milaneschi,Christine M. Mueller,M Huq,Efthymia Vlachopoulou,Lyytikäinen L-P.,Christopher Oldmeadow,Joris Deelen,Markus Perola,Jing Hua Zhao,Bjarke Feenstra,Marzyeh Amini,Jari Lahti,Katharina E. Schraut,Myriam Fornage,Bhoom Suktitipat,Chen W-M.,Xiaohui Li,Teresa Nutile,Giovanni Malerba,Jian'an Luan,Tom Bak,Nicholas J. Schork,Elisabeth Thiering,Anubha Mahajan,Riccardo E. Marioni,Evelin Mihailov,Joel Eriksson,Ayse Bilge Ozel,Weihua Zhang,Maria Nethander,Cheng Y-C.,Stella Aslibekyan,Wei Ang,Ilaria Gandin,Loic Yengo,Laura Portas,Charles Kooperberg,Edith Hofer,Kumar B. Rajan,Claudia Schurmann,W. den Hollander,Tarunveer S. Ahluwalia,Jing Zhao,Draisma Hhm.,Ian Ford,Nicholas J. Timpson,Alexander Teumer,Hongyan Huang,Simone Wahl,Yongmei Liu,Jinyan Huang,Uh H-W.,Frank Geller,Peter K. Joshi,Lisa R. Yanek,Elisabetta Trabetti,Benjamin Lehne,Diego Vozzi,M Verbanck,Ginevra Biino,Yasaman Saba,Ingrid Meulenbelt,Jeffery R. O'Connell,Markku Laakso,Franco Giulianini,Magnusson Pke.,Christie M. Ballantyne,J-J Hottenga,Grant W. Montgomery,Fernando Rivadineira,Rico Rueedi,Maristella Steri,Herzig K-H.,David J. Stott,Cristina Menni,Mattias Frånberg,B. St Pourcain,Stephan B. Felix,Tune H. Pers,Bakker Sjl.,Peter Kraft,Annette Peters,Dhananjay Vaidya,Graciela Delgado,Jan H. Smit,V Großmann,Juha Sinisalo,Ilkka Seppälä,Stephen R. Williams,Elizabeth G. Holliday,Matthijs Moed,Claudia Langenberg,Katri Räikkönen,Jun Ding,Harry Campbell,Michèle M. Sale,Chen Y-Di.,Chen Y-Di.,Alan James,Daniela Ruggiero,Nicole Soranzo,Catharina A. Hartman,Erin N. Smith,Gerald S. Berenson,Christian Fuchsberger,Dena G. Hernandez,Tiesler Cmt.,Vilmantas Giedraitis,D C Liewald,Krista Fischer,Dan Mellström,Anders Larsson,Yajuan Wang,William R. Scott,Mattias Lorentzon,John Beilby,Kathleen A. Ryan,Craig E. Pennell,Dragana Vuckovic,Beverley Balkau,Maria Pina Concas,Reinhold Schmidt,C. F. Mendes de Leon,C. F. Mendes de Leon,Erwin P. Bottinger,Margreet Kloppenburg,Lavinia Paternoster,Michael Boehnke,Arthur W. Musk,Gonneke Willemsen,David M. Evans,Madden Paf.,Mika Kähönen,Zoltán Kutalik,Magdalena Zoledziewska,Ville Karhunen,Stephen B. Kritchevsky,Naveed Sattar,Genevieve Lachance,Robert Clarke,T.B. Harris,Olli T. Raitakari,John Attia,D. van Heemst,Eero Kajantie,Rossella Sorice,Giovanni Gambaro,Robert A. Scott,Andrew A. Hicks,Luigi Ferrucci,M. Standl,Cecilia M. Lindgren,John M. Starr,Magnus Karlsson,Lars Lind,Jun Li,John C. Chambers,Trevor A. Mori,de Geus Ejcn.,A. C. Heath,Nicholas G. Martin,Juha Auvinen,Brendan M. Buckley,de Craen Ajm.,M. Waldenberger,Konstantin Strauch,Thomas Meitinger,R. J. Scott,Mark McEvoy,Marian Beekman,Cristina Bombieri,Paul M. Ridker,Karen L. Mohlke,Nancy L. Pedersen,A C Morrison,Dorret I. Boomsma,John Whitfield,David P. Strachan,Albert Hofman,Peter Vollenweider,Francesco Cucca,Jarvelin M-R.,Joop Jukema,Tim D. Spector,Anders Hamsten,Tanja Zeller,André G. Uitterlinden,Matthias Nauck,Vilmundur Gudnason,Lu Qi,H Grallert,Ingrid B. Borecki,Jerome I. Rotter,W. März,Philipp S. Wild,Lokki M-L.,Michael Boyle,Veikko Salomaa,Mads Melbye,Johan G. Eriksson,James F. Wilson,Penninx Bwjh.,Diane M. Becker,B. B. Worrall,Greg Gibson,Ronald M. Krauss,Marina Ciullo,Gianluigi Zaza,Nicholas J. Wareham,Albertine J. Oldehinkel,Lyle J. Palmer,Sarah S. Murray,Peter P. Pramstaller,Stefania Bandinelli,Joachim Heinrich,Erik Ingelsson,Ian J. Deary,Reedik Mägi,Liesbeth Vandenput,P. van der Harst,Karl C. Desch,Jaspal S. Kooner,Claes Ohlsson,Caroline Hayward,Terho Lehtimäki,Alan R. Shuldiner,Donna K. Arnett,Lawrie J. Beilin,Antonietta Robino,Philippe Froguel,Mario Pirastu,T. Jess,Wolfgang Koenig,Loos Rjf.,Denis A. Evans,Helena Schmidt,George Davey Smith,P E Slagboom,Gudny Eiriksdottir,Andrew P. Morris,Bruce M. Psaty,Russel Tracy,Ilja M. Nolte,Eric Boerwinkle,Sophie Visvikis-Siest,Alexander P. Reiner,Myron D. Gross,J. C. Bis,Lude Franke,Oscar H. Franco,E J Benjamin,Daniel I. Chasman,Josée Dupuis,Harold Snieder,Abbas Dehghan,Behrooz Z. Alizadeh +286 more
TL;DR: In this article, the authors performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals.
Journal ArticleDOI
Loci associated with ischaemic stroke and its subtypes (SiGN) : A genome-wide association study
Sara L. Pulit,Patrick F. McArdle,Quenna Wong,Rainer Malik,Katrina Gwinn,Sefanja Achterberg,Ale Algra,Philippe Amouyel,Christopher D. Anderson,Donna K. Arnett,Ethem Murat Arsava,John Attia,Hakan Ay,Traci M. Bartz,Thomas W.K. Battey,Oscar R. Benavente,Steve Bevan,Alessandro Biffi,Joshua C. Bis,Susan H. Blanton,Giorgio B. Boncoraglio,Robert D. Brown,Annette I. Burgess,Caty Carrera,Sherita N Chapman Smith,Daniel I. Chasman,Ganesh Chauhan,Wei-Min Chen,Yu-Ching Cheng,Michael Chong,Lisa Cloonan,John W. Cole,Ioana Cotlarciuc,Carlos Cruchaga,Elisa Cuadrado-Godia,Tushar Dave,Jesse Dawson,Stéphanie Debette,Hossein Delavaran,Cameron A Dell,Martin Dichgans,Kimberly F. Doheny,Chuanhui Dong,David Duggan,Gunnar Engström,Michele K. Evans,Xavier Estivill Pallejà,Jessica D. Faul,Israel Fernandez-Cadenas,Myriam Fornage,Philippe M. Frossard,Karen L. Furie,Dale M Gamble,Christian Gieger,Anne-Katrin Giese,Eva Giralt-Steinhauer,Hector M. González,An Goris,Solveig Gretarsdottir,Raji P. Grewal,Ulrike Grittner,Stefan Gustafsson,Buhm Han,Graeme J. Hankey,Laura Heitsch,Peter Higgins,Marc C. Hochberg,Elizabeth G. Holliday,Jemma C. Hopewell,Richard B. Horenstein,George Howard,M. Arfan Ikram,Andreea Ilinca,Erik Ingelsson,Marguerite R. Irvin,Rebecca D. Jackson,Christina Jern,Jordi Jimenez Conde,Julie A. Johnson,Katarina Jood,Muhammad S Kahn,Robert C. Kaplan,L. Jaap Kappelle,Sharon L.R. Kardia,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Simon A. Koblar,Daniel L. Labovitz,Lenore J. Launer,Cathy C. Laurie,Cecelia A. Laurie,Cue Hyunkyu Lee,Jin-Moo Lee,Manuel Lehm,Robin Lemmens,Christopher Levi,Didier Leys,Arne Lindgren,W. T. Longstreth,Jane Maguire,Ani Manichaikul,Hugh S. Markus,Leslie A. McClure,Caitrin W. McDonough,Christa Meisinger,Olle Melander,James F. Meschia,Marina Mola-Caminal,Joan Montaner,Thomas H. Mosley,Martina Müller-Nurasyid,Mike A. Nalls,Jeffrey R. O'Connell,Martin O'Donnell,Angel Ois,George J. Papanicolaou,Guillaume Paré,Leema Reddy Peddareddygari,Annie Pedersen,Joanna Pera,Annette Peters,D Poole,Bruce M. Psaty,Raquel Rabionet,Miriam R. Raffeld,Kristiina Rannikmäe,Asif Rasheed,Petra Redfors,Alexander P. Reiner,Kathryn M. Rexrode,Marta Ribasés,Stephen S. Rich,Wim Robberecht,Ana Rodríguez-Campello,Arndt Rolfs,Jaume Roquer,Lynda M. Rose,Daniel Rosenbaum,Natalia S. Rost,Peter M. Rothwell,Tatjana Rundek,Kathleen A. Ryan,Ralph L. Sacco,Michèle M. Sale,Danish Saleheen,Veikko Salomaa,Cristina Sánchez-Mora,Carsten Oliver Schmidt,Helena Schmidt,Reinhold E. Schmidt,Markus Schürks,Rodney J. Scott,Helen Segal,Stephan Seiler,Sudha Seshadri,Pankaj Sharma,Alan R. Shuldiner,Brian Silver,Agnieszka Slowik,Jennifer A. Smith,Martin Söderholm,Carolina Soriano,Mary J. Sparks,Tara M. Stanne,Kari Stefansson,O. Colin Stine,Konstantin Strauch,Jonathan Sturm,Cathie Sudlow,Salman M. Tajuddin,Robert L. Talbert,Turgut Tatlisumak,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteindottir,Steffen Tiedt,Matthew Traylor,Stella Trompet,Valerie Valant,Melanie Waldenberger,Matthew Walters,Liyong Wang,Sylvia Wassertheil-Smoller,David R. Weir,Kerri L. Wiggins,Stephen R. Williams,Dorota Wloch-Kopec,Daniel Woo,Rebecca Woodfield,Ona Wu,Huichun Xu,Alan B. Zonderman,Bradford B. Worrall,Paul I.W. de Bakker,Steven J. Kittner,Braxton D. Mitchell,Jonathan Rosand,Cathie L. M. Sudlow,Bradford B. Worrall,Donna K. Arnett,Oscar R. Benavente,Sylvia Wasssertheil-Smoller +202 more
TL;DR: A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke was identified and supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies.