Showing papers by "Charlie Norwood VA Medical Center published in 2008"
TL;DR: Examination of tumor-bearing animals and identification of novel renoprotective strategies that do not diminish the anticancer efficacy of cisplatin are essential to the development of clinically applicable interventions.
1,482 citations
TL;DR: In this paper, the authors found that administration of cisplatin induced the formation of autophagic vesicles and autophagosomes in mouse kidneys, and this was partially suppressed by the p53 inhibitor pifithrin-α.
306 citations
TL;DR: Flow and change in flow are inaccurate predictors of thrombosis and intervention based on surveillance likely yields many unnecessary procedures, and this study does not support routine application of surveillance to prevent thromBosis.
33 citations
TL;DR: Inflows stenosis exerts its most important haemodynamic effect through its interaction with outflow stenosis, which has an important impact on graft haemodynamics and surveillance because of its location in the relatively narrow inflow tract.
Abstract: Background. Recent studies have shown that inflow stenosisofhaemodialysisgraftsismorecommonthanpreviously realized. The influence of inflow stenosis on graft haemodynamics and venous pressure (VP) surveillance has not been previously systematically studied. Methods. We used a well-established mathematical model to determine the relation between inflow stenosis and static VP(adjustedformeanarterialpressure,VP/MAP),outflow stenosis and artery and vein luminal diameters. We applied low, median and high ratios of artery/vein diameters from 94 patients with grafts. The median ratio was 0.77, indicating that the artery was generally narrower than the vein. Results. The model shows that inflow stenosis reduces VP/MAP. More importantly, however, as outflow stenosis progresses, fixed inflow stenosis causes a delayed increase in VP/MAP followed by a rapid increase at critical outflow stenosis. When both stenoses progress together, their relative rates determine whether and how rapidly VP/MAP increases. The increase in VP/MAP is remarkably abrupt when the rate of inflow stenosis approaches that of outflow stenosis. No increase occurs when inflow stenosis progresses as fast or faster than outflow stenosis. Conclusion. Inflow stenosis exerts its most important haemodynamic effect through its interaction with outflow stenosis. As outflow stenosis progresses, inflow stenosis causes a delayed and then rapid increase in VP/MAP at critical outflow stenosis. This increase may not be detected before thrombosis unless measurements are very frequent. Inflow stenosis has an important impact on graft haemodynamics and surveillance because of its location in the relatively narrow inflow tract.
13 citations
TL;DR: Rheumatoid arthritis is a chronic, destructive, autoimmune joint disease that affects one to two million Americans (or approximately 1% of the population of the United States) and indeed, anti-inflammatory drugs are a mainstay of treatment.
5 citations