M
Man Jiang
Researcher at Georgia Regents University
Publications - 10
Citations - 1825
Man Jiang is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Cisplatin & Apoptosis. The author has an hindex of 9, co-authored 10 publications receiving 1636 citations. Previous affiliations of Man Jiang include Charlie Norwood VA Medical Center.
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Journal ArticleDOI
Autophagy in proximal tubules protects against acute kidney injury
TL;DR: The results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms and establish a renal proximal tubule-specific Autophagy-related gene 7 knockout mouse model.
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Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
TL;DR: In vivo and in vitro models of ischemia-reperfusion demonstrated autophagy induction during hypoxic and ischemic renal injury and suggested that under these pathological conditions,autophagy may provide a protective mechanism for cell survival.
Journal ArticleDOI
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells
Sudharsan Periyasamy-Thandavan,Man Jiang,Qingqing Wei,Robert M. Smith,Xiao Ming Yin,Zheng Dong,Zheng Dong +6 more
TL;DR: In this paper, the authors found that administration of cisplatin induced the formation of autophagic vesicles and autophagosomes in mouse kidneys, and this was partially suppressed by the p53 inhibitor pifithrin-α.
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Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.
TL;DR: An important role is found for p53 in cisplatin-induced apoptosis in renal tubular cells and the results suggest that p53 activation might be an early signal for apoptosis during cisPlatin treatment.
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Autophagy: molecular machinery, regulation, and implications for renal pathophysiology
TL;DR: The molecular machinery, regulation, and function of autophagy, a cellular process of "self-eating" that can directly induce cell death or act as a mechanism of cell survival, is discussed.