Institution
Clinical Emergency Hospital Bucharest
Healthcare•Bucharest, Romania•
About: Clinical Emergency Hospital Bucharest is a healthcare organization based out in Bucharest, Romania. It is known for research contribution in the topics: Medicine & Internal medicine. The organization has 381 authors who have published 276 publications receiving 2188 citations. The organization is also known as: Floreasca Hospital & Spitalul Floreasca.
Topics: Medicine, Internal medicine, Population, Cancer, Pregnancy
Papers published on a yearly basis
Papers
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16 Jul 2020
TL;DR: In women of fertile age, before initiating statin treatment, contraception methods should be discussed because statins may have teratogenic effects, and older women have a higher likelihood of polypharmacy, with greater potential for drug interactions when prescribing a statin.
Abstract: Despite major progress in the prevention and treatment of cardiovascular diseases, women remain an underdiagnosed and insufficiently treated group, with higher hospitalization and death rates compared to men. Obesity, more frequently encountered in women, raises the risk of metabolic syndrome and cardiovascular diseases as women age. There are some differences based on sex regarding the screening, diagnosis, and treatment of dyslipidemia, as it has been observed that women are less frequently prescribed statins and, when they are, they receive lower doses, even after myocardial infarction or coronary revascularization. Real-life data show that, compared to men, women are at higher risk of non-adherence to statin treatment and are more predisposed to discontinue treatment because of side effects. Statin metabolism has some particularities in women, due to a lower glomerular filtration rate, higher body fat percentage, and overall faster statin metabolism. In women of fertile age, before initiating statin treatment, contraception methods should be discussed because statins may have teratogenic effects. Older women have a higher likelihood of polypharmacy, with greater potential for drug interactions when prescribing a statin.
39 citations
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TL;DR: The prevalence of pancreatic exocrine insufficiency in advanced pancreatic cancer is substantial and its treatment can improve the outcomes of these patients.
Abstract: BackgroundPancreatic cancer is the fourth leading cause of cancer mortality. Most patients are diagnosed with advanced pancreatic cancer, either at locally advanced or metastatic stages, and have a...
37 citations
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TL;DR: The use of GLP-1RAs was associated with a significant reduction of cardiovascular and all-cause mortality, with a safe profile related to pancreatitis or thyroid cancer, as compared with placebo, and ongoing trials assess the cardiovascular benefits and side effects of dulaglutide treatment.
Abstract: Patients with type 2 diabetes exhibit higher cardiovascular risk than normal individuals. Optimal blood glucose levels are rarely achieved in diabetic patients. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a new antidiabetic drug class with multiple metabolic effects. Some trials have evaluated their safety, but it has been recently demonstrated that this new class has cardiovascular benefits, through other mechanisms than glycemic control. The use of GLP-1RAs was associated with a significant reduction of cardiovascular and all-cause mortality, with a safe profile related to pancreatitis or thyroid cancer, as compared with placebo. This review presents the cardiovascular and metabolic benefits of GLP-1 RAs versus placebo, in patients with type 2 diabetes. Semaglutide and liraglutide demonstrated a reduction in cardiovascular events, with similar rates on cardiovascular mortality. Ongoing trials assess the cardiovascular benefits and side effects of dulaglutide treatment. Exenatide and liraglutide demonstrated the decrease of blood pressure values, weight reduction and improvement of dyslipidemia. Liraglutide induced, both in vivo and in vitro, an improvement of blood circulation, increasing the nitric oxide level and inhibiting the adhesion and procoagulant factors. Also, liraglutide demonstrated beneficial effects on cardiac remodeling after myocardial infarction, but more large trials are required. However, the international guidelines recommend using GLP-1 RAs as first-line therapy in type 2 diabetes patients with high cardiovascular risk or as first-line agents in patients intolerant to metformin.
37 citations
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TL;DR: In this paper, drugs targeting the PI3K/AKT/mTOR signalling pathway may be one of the best therapeutic options for RCC, and Temsirolimus and everolimus are two mTOR inhibitors are currently used for the treatment of RCC.
Abstract: Renal cell carcinoma (RCC) accounts for over 90% of all renal malignancies, and mainly affects the male population. Obesity and smoking are involved in the pathogenesis of several systemic cancers including RCC. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway regulates cell growth, differentiation, migration, survival, angiogenesis, and metabolism. Growth factors, hormones, cytokine and many extracellular cues activate PI3K/AKT/mTOR. Dysregulation of this molecular pathway is frequently reported in human cancers including RCC and is associated with aggressive development and poor survival rate. mTOR is the master regulator of cell metabolism and growth, and is activated in many pathological processes such as tumour formation, insulin resistance and angiogenesis. mTOR inhibitors are used at present as drug therapy for RCC to inhibit cell proliferation, growth, survival, and the cell cycle. Temsirolimus and everolimus are two mTOR inhibitors that are currently used for the treatment of RCC. Drugs targeting the PI3K/AKT/mTOR signalling pathway may be one of the best therapeutic options for RCC.
36 citations
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TL;DR: In this paper, the authors identify the predictors of burnout in healthcare workers during the COVID-19 pandemic, identifying three job demands (work-family conflict, lack of preparedness/scope of practice, emotional demands), three job resources (training, professional development, and continuing education; supervision, recognition, and feedback; autonomy and control), and one personal resource (selfefficacy) were significant predictors for burnout, explaining together 37% of the variance of healthcare workers' burnout.
35 citations
Authors
Showing all 397 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bogdan A. Popescu | 65 | 284 | 69502 |
Ionut Negoi | 43 | 168 | 29046 |
Mihaela Hostiuc | 21 | 45 | 11644 |
Maria Dorobantu | 15 | 57 | 634 |
Camelia Cristina Diaconu | 15 | 185 | 990 |
Ioan Lascar | 14 | 83 | 484 |
Razvan Multescu | 13 | 68 | 674 |
Daniela Bartos | 12 | 57 | 1755 |
Cristian Balalau | 12 | 86 | 405 |
Bogdan Socea | 11 | 138 | 557 |
Gelu Onose | 11 | 61 | 706 |
Valentin Titus Grigorean | 10 | 40 | 467 |
Elisabeta Badila | 10 | 38 | 432 |
Octav Ginghina | 10 | 27 | 252 |
O. Tautu | 9 | 13 | 3109 |