Innlandet Hospital Trust

About: Innlandet Hospital Trust is a healthcare organization based out in Brumunddal, Norway. It is known for research contribution in the topics: Population & Dementia. The organization has 387 authors who have published 1302 publications receiving 37753 citations.

The quality of life and factors associated with it in the medically hospitalised elderly.

Abstract: Aim: The present study describes the quality of life (QOL) and explores health-related factors associated with domains of the QOL in the acutely ill and hospitalised elderly Method: In all, 484 elderly (65–101 years, 241 men) patients hospitalised in an acute medical unit participated Their QOL (in its overall and physical, psychological, social and environmental domains) was assessed with the World Health Organisation's WHOQOL-BREF The QOL was explored with multiple linear regression analysis Health-related variables controlled for socio-demographic background were the independent variables Results: The overall QOL was good in two-thirds of the elderly patients In multiple linear regression models, lower physical QOL was significantly associated with a number of medications, impaired personal activities of daily living (PADL), impaired cognition, depression and anxiety Lower psychological QOL was significantly associated with impaired PADL, impaired cognition, depression and anxiety Lower social

Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia.

Abstract: Background Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for late cardiotoxic effects of cancer treatment, but conflicting evidence exists on the effects of anthracyclines on left ventricular (LV) diastolic function and exercise capacity. Procedure We performed a cross-sectional study with comprehensive echocardiography in 138 adult survivors of childhood ALL, median 23.4 years after diagnosis. Pulsed tissue Doppler measurements of early diastolic mitral annular velocities (e’) were used for the assessment of diastolic function, and compared to 138 matched controls. Of the survivors, 133 also performed ergospirometry measuring peak oxygen uptake (VO2max). Associations between cancer treatment, LV function, and VO2max were analyzed. Results The survivor group had lower e’ values than controls (e’ septal 11.0 vs. 12.6 cm/s, P < 0.001), but the difference was confined to the subgroup of anthracycline treated survivors (median cumulative dose 120 mg/m2). Anthracycline exposure was inversely correlated with e’ (regression coefficient −1.581, P = 0.009). Reduced VO2max/kg occurred in 47% of the survivors, but more often in anthracycline treated survivors (56%) than anthracycline naive survivors (17%, P < 0.001). Anthracycline exposure was inversely correlated with VO2max/kg (regression coefficient −3.084, P = 0.05 in multivariate analysis). Furthermore, associations were observed between measures of LV function and VO2max/kg, and e’ was the best predictor of VO2max/kg (standardized coefficient 0.355, P < 0.001 in multivariate analysis). Conclusions Adult survivors of childhood ALL have increased risk for impaired LV diastolic function and impaired exercise capacity, both associated with previous anthracycline exposure. Furthermore, there is an association between LV diastolic function and exercise capacity. Pediatr Blood Cancer 2015;62:1437–1443. © 2015 Wiley Periodicals, Inc.

Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia.

Abstract: Background/Aims: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer’s disease, vascular dementia or both.

The prevalence of anemia and iron deficiency is more common in breastfed infants than their mothers in Bhaktapur, Nepal

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