Institute of Process Engineering

About: Institute of Process Engineering is a facility organization based out in . It is known for research contribution in the topics: Chemistry & Catalysis. The organization has 72 authors who have published 238 publications receiving 1694 citations. The organization is also known as: Institute of Chemical Metallurgy, Chinese Academy of Sciences.

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

Abstract: Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. While K(L-la) can be introduced by the acetyltransferase p300, histone delactylases enzymes remained unknown. Here, we report the systematic evaluation of zinc- and nicotinamide adenine dinucleotide–dependent histone deacetylases (HDACs) for their ability to cleave ε- N -L-lactyllysine marks. Our screens identified HDAC1–3 and SIRT1–3 as delactylases in vitro. HDAC1–3 show robust activity toward not only K(L-la) but also K(D-la) and diverse short-chain acyl modifications. We further confirmed the de-L-lactylase activity of HDACs 1 and 3 in cells. Together, these data suggest that histone lactylation is installed and removed by regulatory enzymes as opposed to spontaneous chemical reactivity. Our results therefore represent an important step toward full characterization of this pathway’s regulatory elements.

Recent progress of thermal conductive ploymer composites: Al2O3 fillers, properties and applications

Abstract: Thermal conductive polymer composites attract lots of research due to the continuous miniaturization and multi-function of electronic equipment. As a common ceramic, Al2O3 owns relatively high thermal conductivity, high electrical resistivity and satisfactory cost performance, which is considered as the high-quality filler to prepare thermal conductive and electrical insulated composites. This paper reviews current progress in the development of Al2O3 reinforced polymer composites. We firstly summarize the preparation methods of spherical Al2O3, then heat conduction mechanisms and main factors affecting thermal conductivity are introduced. Next, we focus on the common research of Al2O3 in improving the thermal conductivity of polymers, including surface modification, filler hybridization and construction of Al2O3 network by various processing methods, and some emerging applications of thermal conductive polymer composites are introduced subsequently. After a critique of recent studies, we identify several outstanding issues must be addressed if higher thermal conductivity is fully realized.

Artificial frustrated Lewis pairs facilitating the electrochemical N2 and CO2 conversion to urea

Abstract: Frustrated Lewis pairs (FLPs) containing sterically hindered Lewis acidic and basic sites can capture and react with N2 and CO2, thus furnishing a new strategy for urea electrosynthesis. Herein, the rice-like InOOH nanoparticles coupled with the well-defined FLPs (i.e., In In-OH) were synthesized and exhibited a urea yield rate of 6.85 mmol h−1 g−1 and faradic efficiency of 20.97% at −0.4 V versus reversible hydrogen electrode. Systematic investigations reveal that the electron-deficient Lewis acidic In sites and electron-rich Lewis basic In-OH achieve the targeted chemisorption of the N2 and CO2 molecules by electronic interaction respectively. The bonding and antibonding orbitals of reactant molecules interact with the unoccupied orbitals of Lewis acid and nonbonding orbitals of Lewis base to generate the desired intermediates for urea synthesis in artificial FLPs. In addition, FLPs can further ensure the orbital-matched intermediates of ∗N=N∗ and CO proceed with the desirable C–N coupling reaction to produce ∗NCON∗ precursors.