Institution
Korean Ocean Research and Development Institute
Facility•Busan, South Korea•
About: Korean Ocean Research and Development Institute is a facility organization based out in Busan, South Korea. It is known for research contribution in the topics: Sea surface temperature & Gene. The organization has 1770 authors who have published 3032 publications receiving 50142 citations.
Topics: Sea surface temperature, Gene, Sediment, Bay, Population
Papers published on a yearly basis
Papers
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TL;DR: It is revealed that Mlc possesses a built-in flexibility for the structural adaptation to its target DNA and that interaction of Mlc with EIIB fused only to dimeric proteins resulted in the loss of itsDNA binding ability, suggesting that flexibility of the Mlc structure is indispensable for its DNA binding.
Abstract: In Escherichia coli, glucose-dependent transcriptional induction of genes encoding a variety of sugar-metabolizing enzymes and transport systems is mediated by the phosphorylation state-dependent interaction of membrane-bound enzyme IICBGlc (EIICBGlc) with the global repressor Mlc. Here we report the crystal structure of a tetrameric Mlc in a complex with four molecules of enzyme IIBGlc (EIIB), the cytoplasmic domain of EIICBGlc. Each monomer of Mlc has one bound EIIB molecule, indicating the 1:1 stoichiometry. The detailed view of the interface, along with the high-resolution structure of EIIB containing a sulfate ion at the phosphorylation site, suggests that the phosphorylation-induced steric hindrance and disturbance of polar intermolecular interactions impede complex formation. Furthermore, we reveal that Mlc possesses a built-in flexibility for the structural adaptation to its target DNA and that interaction of Mlc with EIIB fused only to dimeric proteins resulted in the loss of its DNA binding ability, suggesting that flexibility of the Mlc structure is indispensable for its DNA binding.
54 citations
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TL;DR: Reduced summer metabolism as compared with temperate bivalve species appears to be an important strategy of energy conservation of L. elliptica inhabiting Antarctic nearshore areas where food may be in short supply for up to 9 months of the year.
54 citations
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TL;DR: Understanding on diverse chemical structures of triterpene glycosides from various species of sea cucumbers and their important biological activities are updated and summarized.
Abstract: Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holostane and nonholostane depending on the presence or absence of a specific structural unit γ(18,20)-lactone in the aglycone. Triterpene glycosides contain a carbohydrate chain up to six monosaccharide units mainly consisting of d-xylose, 3-O-methy-d-xylose, d-glucose, 3-O-methyl-d-glucose, and d-quinovose. Cytotoxicity is the common biological property of triterpene glycosides isolated from sea cucumbers. Besides cytotoxicity, triterpene glycosides also exhibit antifungal, antiviral and hemolytic activities. This review updates and summarizes our understanding on diverse chemical structures of triterpene glycosides from various species of sea cucumbers and their important biological activities. Mechanisms of action and structural–activity relationships (SARs) of sea cucumber glycosides are also discussed briefly.
54 citations
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TL;DR: The regenerative capacity of sea cucumber makes it a medically important organism, and the various biological activities and biomedical potential of Sea cucumber S. japonicus are presented.
Abstract: Members of the phylum Echinodermata, commonly known as echinoderms, are exclusively marine invertebrates. Among the Echinodermata, sea cucumber belongs to the family Holothuroidea. The sea cucumber Stichopus (Apostichous) japonicus (Selenka) is an invertebrate animal inhabiting the coastal sea around Korean, Japan, China, and Russia. Sea cucumber has a significant commercial value, because it contains valuable nutrients such as vitamins and minerals. They possess a number of distinctive biologically and pharmacologically important compounds. In particular, the body wall of sea cucumber is a major edible part. It consists of peptide, collagen, gelatin, polysaccharide, and saponin, which possess several biological activities such as anti-cancer, anti-coagulation, anti-oxidation, and anti-osteoclastogenesis. Furthermore, the regenerative capacity of sea cucumber makes it a medically important organism. This review presents the various biological activities and biomedical potential of sea cucumber S. japonicus.
54 citations
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TL;DR: The compartment model POSEIDON-R was modified and applied to the Northwestern Pacific and adjacent seas to simulate the transport and fate of radioactivity in the period 1945-2010, and to perform a radiological assessment on the releases ofRadioactivity due to the Fukushima Dai-ichi accident for the period 2011-2040.
54 citations
Authors
Showing all 1787 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ian H. Campbell | 75 | 204 | 18767 |
Ravi Shankar | 66 | 672 | 19326 |
Claude F. Boutron | 57 | 176 | 11220 |
Carlo Barbante | 56 | 347 | 13942 |
Won Joon Shim | 56 | 211 | 10099 |
Jong-Seong Kug | 49 | 248 | 11337 |
Dong-Gyu Jo | 47 | 167 | 7599 |
Jong Seok Lee | 46 | 399 | 11661 |
Jong Seong Khim | 43 | 235 | 6783 |
Sang Hee Hong | 41 | 98 | 5804 |
Paolo Cescon | 40 | 131 | 4161 |
Jung-Hyun Lee | 38 | 215 | 5045 |
Narayanan Kannan | 38 | 140 | 6116 |
Nan Li | 38 | 183 | 5184 |
Sungmin Hong | 35 | 99 | 4130 |