Showing papers by "Lenox Hill Hospital published in 1975"
TL;DR: Autologous antibodies recovered from peritoneal effusions will be hopefully utilized in sensitive radioimmunoassay tests that are greatly needed for the early detection of ovarian cancer, the leading cause of death from gynecologic neoplasia.
Abstract: Peritoneal effusions of patients with ovarian cancer contain sizable amounts of free and complexed immunoglobulins. By means of salt precipitation procedures, antibodies were recovered that after purification and concentration displayed a high degree of specificity against ovarian carcinoma cells. In indirect immunofluorescence, immunoglobulins recovered from seven different peritoneal effusions showed bright cytoplasmic staining with tissue cultures and fresh suspensions of ovarian carcinoma cells but not of normal ovaries or non-ovarian tumors. Immunoglobulins isolated from fluids of benign ovarian cysts or from effusions of non-ovarian tumors were negative in immunofluorescence tests. Autologous antibodies recovered from peritoneal effusions will be hopefully utilized in sensitive radioimmunoassay tests that are greatly needed for the early detection of ovarian cancer, the leading cause of death from gynecologic neoplasia.
41 citations
TL;DR: The acute inflammation of ulcerative colitis, as indicated by neutrophils, was decreased most notably following therapy with prednisone or 6-mercaptopurine, and chronic inflammation associated with fewer plasma cells was decreased after salicylazosulfapyridine as well as either of the other two drugs.
Abstract: Epithelial and connective-tissue cells were counted in rectal mucosal biopsies from 215 patients with ulcerative colitis, 98 patients with granulomatous colitis, and 50 controls. The results were analyzed statistically. Significantly decreased mucous goblet cells were found both in sigmoidoscopically abnormal ulcerative colitis and in granulomatous colitis, and they increased during the healing process. More pyknotic and karyorrhectic epithelial cells occurred in active ulcerative colitis than in granulomatous colitis. Inactive ulcerative colitis still manifested histologic evidence of acute and chronic inflammation, while sigmoidoscopically normal granulomatous colitis biopsies after previous gross rectal disease showed significantly increased macrophages in the lamina propria. Cell counts were valuable for differential diagnosis after the sigmoidoscopic appearance became normal. The acute inflammation of ulcerative colitis, as indicated by neutrophils, was decreased most notably following therapy with prednisone or 6-mercaptopurine. Chronic inflammation associated with fewer plasma cells was decreased after salicylazosulfapyridine as well as either of the other two drugs; macrophages, indicators of healing, increased most after 6-mercaptopurine combined with another anti-inflammatory agent.
38 citations
TL;DR: The data suggest that cellular immune mechanisms may be involved in the host response to cells bearing tumor-specific antigens, and that cellular immunological responsiveness to ovarian carcinomas is unknown.
12 citations
TL;DR: The anatomic configuration of the right ventricle makes repair through a right atriotomy more suitable, and the advantages of this approach are discussed and a case report is presented.
10 citations
TL;DR: It is suggested that peripheral nerve stimulation, like arousal, may cause an outflow of ACh on the normal brain surface and over the open end of a partially isolated area, which, especially, in the presence of a diminished cholinesterase activity (in partially isolated cortex), could act like topical ACh, cause a DC shift and an epileptiform discharge.
9 citations
TL;DR: It was found that lymphoma cells that replicate GLV and display membrane and cytoplasmic GLV-associated antigens are consistently rejected when transplanted into syngeneic recipients, while those derived from the same parental cell line and morphologically indistinguishable were accepted and grew progressively at primary and metastatic sites.
Abstract: The capacity for syngeneic transplantation of rat lymphoma cells, originally induced by Gross lymphoma virus (GLV), was correlated with the expression of GLV-associated antigens by these cells. It was found that lymphoma cells that replicate GLV and display membrane and cytoplasmic GLV-associated antigens are consistently rejected when transplanted into syngeneic recipients. By contrast, lymphoma cells derived from the same parental cell line and morphologically indistinguishable, that have lost both surface and cytoplasmic antigenic expression were accepted and grew progressively at primary and metastatic sites. In further experiments, a long-lasting state of specific immunologic unresponsiveness was induced by administration of soluble GLV-associated antigens to newborn rats. These rats were later grafted with GLV-induced lymphoma cells that were positive for both membrane and cytoplasmic antigens. The rats conditioned at birth accepted the grafts which grew progressively, in contrast to normal controls which rejected them consistently. However, the grafted lymphoma cells showed progressive loss of antigenic determinants, and became serially transplantable in normal adult non conditioned rats. The membrane antigens were first to disappear from the grafted lymphoma cells, followed by the internal cytoplasmic antigens in further transplant generations. The transplantability of these cells increased accordingly. Titers of anti-GLV sera in tumor-bearing rats remained high even after surface antigens of lymphoma cells were no longer detected, but decreased to baseline levels after the internal antigens had been similarly lost.
3 citations
TL;DR: This finding suggests that release of a control mecha nism or pituitary stimulation of a latent factor may trigger tumor development and that tumors generally have a higher degree of virulence as a result of the child's less effective immunologic defenses.
Abstract: cancer in a child is surpassed only by confusion over treatment. Although the ovary is the most common site of gyne cologic tumors in children, fortunately. only one in 10 is malignant. Ovarian neoplasms may occur at any time in childhood or adolescence, but tend to be more frequent between the ages of 10 and 14 years. This finding suggests that release of a control mecha nism or pituitary stimulation of a latent factor may trigger tumor development. Ovarian cancer poses certain prob lems in children that are not as signifi cant in adults: it is associated with in creased cachexia and ascites; larger tumors cause relatively greater pressure symptoms and dyspnea: evolution is more rapid, due to the limited space for tumor expansion; tumors generally have a higher degree of virulence as a result of the child's less effective immunologic defenses. Of course, the effects of ther apy on a child's future development must always be considered.
1 citations
TL;DR: This poster explains the rationale behind the continuous Intravenous Infusion of Small Doses of Insulin in Treatment of Diabetic Ketoacidosis and some of the principles behind its use.
Abstract: References 1. Sonksen, P. H., Ellis, J. P., Lowy, G., Rutherford, A. and Nabarro, J. D. N.: Diabetotogia 7:208, 1965. 2. Kidson, W., Casey, J., Kraegen, E. and Lazarus, L. : Treatment of Severe Diabetes Mellitus by Insulin Infusion, Br. Med. J. (June 29) 1974, p. 691. 3. Semple, P. F., White, C. and Manderson, W. G.: Continuous Intravenous Infusion of Small Doses of Insulin in Treatment of Diabetic Ketoacidosis, Br. Med. J. (June 29) 1974, p. 694.