Institution
Nanjing Medical University
Education•Nanjing, China•
About: Nanjing Medical University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Cancer & Cell growth. The organization has 52221 authors who have published 37904 publications receiving 635831 citations. The organization is also known as: National Jiangsu Medical College & Nanjing Medical College.
Topics: Cancer, Cell growth, Medicine, Population, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: A brief summary of vaccine administration-related factors, including vaccination approach, delivery route and method of administration, are provided to gain a better understanding of their potential impact on the safety and immunogenicity of candidate vaccines.
Abstract: The many factors impacting the efficacy of a vaccine can be broadly divided into three categories: features of the vaccine itself, including immunogen design, vaccine type, formulation, adjuvant and dosing; individual variations among vaccine recipients and vaccine administration-related parameters. While much literature exists related to vaccines, and recently systems biology has started to dissect the impact of individual subject variation on vaccine efficacy, few studies have focused on the role of vaccine administration-related parameters on vaccine efficacy. Parenteral and mucosal vaccinations are traditional approaches for licensed vaccines; novel vaccine delivery approaches, including needless injection and adjuvant formulations, are being developed to further improve vaccine safety and efficacy. This review provides a brief summary of vaccine administration-related factors, including vaccination approach, delivery route and method of administration, to gain a better understanding of their potential impact on the safety and immunogenicity of candidate vaccines.
144 citations
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TL;DR: Both low and high education showed a trend of dose-response relation with risk of dementia and AD, and the dementia risk was reduced by 7 % for per year increase in education.
Abstract: Educational level has been regarded as one of the most widely accepted risk factors in the epidemiological studies for dementia, despite with discordant qualitative results. However, the dose-response relation between education and incident dementia was still unknown. To quantitatively evaluate the association between exposure level to high and low education and risk of dementia, we searched PubMed, EMBASE, and the Cochrane Library up to November 2014 and references of retrieved literatures. Specific prospective cohort studies, in which educational attainment was categorized into at least three levels, were included. Newcastle-Ottawa scale was used to assess the quality of included studies. Fifteen prospective cohort studies with 55655 for low education and eight prospective cohort studies with 20172 for high education were included. In the qualitative analysis, both low and high education showed a dose-response trend with risk of dementia and Alzheimer's disease (AD). In the quantitative analysis, the dementia risk was reduced by 7 % for per year increase in education (RR, 0.93; 95 % CI, 0.92-0.94; p for overall trend = 0.000; p for nonlinearity = 0.0643). Nonetheless, we did not find statistically significant association between per year decrease in education and dementia (RR, 1.03; 95 % CI, 0.96-1.10; p for overall trend = 0.283; p for nonlinearity = 0.0041) or AD (RR, 1.03; 95 % CI, 0.97-1.10; p for overall trend = 0.357; p for nonlinearity = 0.0022). Both low and high education showed a trend of dose-response relation with risk of dementia and AD. The dementia risk was reduced by 7 % for per year increase in education.
144 citations
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TL;DR: This study provides the first evidence that temsirolimus promotes autophagic Aβ clearance and exerts protective effects in cellular and animal models of AD, suggesting that Temsiro Limus administration may represent a new therapeutic strategy for AD treatment.
143 citations
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TL;DR: Toddlers and urban boys were at particularly high risk; the prevalence in these groups increased more rapidly than in their counterparts and public health prevention strategies are urgently needed to modify health behaviors of children and adolescents and control overweight/obesity in China.
Abstract: Background
Overweight/obesity is a serious public health problem that affects a large part of the world population across all age and racial/ethnic groups. However, there has not been a meta-analysis of the prevalence of childhood and adolescent overweight/obesity in China during the past 30 years.
143 citations
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TL;DR: Immature oocyte retrieval from ovaries without ovarian stimulation followed by in vitro maturation and vitrification is a promising fertility preservation option for women who cannot undergo ovarian stimulation or cannot delay their gonadotoxic cancer treatment.
143 citations
Authors
Showing all 52549 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
H. S. Chen | 179 | 2401 | 178529 |
Feng Zhang | 172 | 1278 | 181865 |
Yang Yang | 171 | 2644 | 153049 |
Lei Jiang | 170 | 2244 | 135205 |
Peter T. Fox | 131 | 622 | 83369 |
Peter J. Anderson | 120 | 966 | 63635 |
Jinde Cao | 117 | 1430 | 57881 |
John P. Neoptolemos | 112 | 648 | 52928 |
Wei Zhang | 112 | 1189 | 93641 |
Jie Wu | 112 | 1537 | 56708 |
Jinhua Ye | 112 | 658 | 49496 |
Patrick Y. Wen | 109 | 838 | 52845 |
Fei Wang | 107 | 1824 | 53587 |
David C. Christiani | 100 | 1052 | 55399 |