Niigata Seiryo University

About: Niigata Seiryo University is a education organization based out in Niigata, Japan. It is known for research contribution in the topics: Influenza A virus & Virus. The organization has 40 authors who have published 128 publications receiving 2650 citations.

The patient health questionnaire, Japanese version: validity according to the mini-international neuropsychiatric interview-plus.

Abstract: To validate the Japanese version of the Patient Health Questionnaire against the Mini-International Neuropsychiatric Interview-Plus in Japan 131 patients in 4 primary care settings and 2 general hospital settings participated. These patients completed the Patient Health Questionnaire and returned it to their physician within 48 hr. Subsequently, the subjects underwent a diagnostic evaluation interview based on the Mini-International Neuropsychiatric Interview-Plus by an interviewer blind to the results of the Patient Health Questionnaire screening. The Patient Health Questionnaire diagnosis was characterized using kappa values between 0.70 and 1.0 for Somatoform Disorder, Major Depressive Disorder, Panic Disorder, Bulimia Nervosa, Alcohol Abuse/Dependence, and Premenstrual Disorder. Sensitivities, specificities, and negative predictive values were very good (between 0.84 and 1.0) for the first 4 diagnoses but not Alcohol Abuse/Dependence or Premenstrual Disorder, as were the Positive predictive values (between 0.78 and 1.0). Findings show very good concordance of the Japanese version of the Patient Health Questionnaire with the Japanese version of the Mini-International Neuropsychiatric Interview-Plus.

Early-stage carcinoids of the gastrointestinal tract: an analysis of 1914 reported cases.

Abstract: BACKGROUND Gastrointestinal (GI) carcinoids, considered to be endocrine neoplasms with relatively low levels of malignancy, have never been examined in large, statistically reliable series to determine their true aggressive behavior in the early stage of both minute (≤ 5 mm) or small (5.1–10.0 mm) tumors at a depth of invasion restricted to the mucosa and submucosa (sm carcinoids). METHODS Of a total number of 1914 cases of GI sm carcinoids selected from the Niigata Registry, 1614 with the tumor size recorded on a millimeter scale were categorized in 5-mm size intervals and rates of metastases were calculated for those in each size category. Of statistical significance was confirmation that the rectum (n = 849), the stomach (n = 449), the duodenum (n = 349), and the jejunoileum (n = 149) were among the principal growth sites. The Kaplan–Meier method was used to calculate 5-year-survival rates (5YSRs) and a comparative study was undertaken. RESULTS GI sm carcinoids exhibited a metastasis rate of 16.4% (264 of 1614) as a whole and minute carcinoids (≤ 5 mm) revealed an unexpectedly high metastasis rate of 6.0% (24 of 399) on average, which ranged from 3.7% (8 of 216) in the rectum to 17.2% (5 of 29) in the jejunoileum. Small carcinoids measuring 5.1–10 mm also showed a high metastasis rate of 13.3% (90 of 675) on average, ranging from 9.6% (12 of 125) in the stomach to 41.2% (14 of 34) in the jejunoileum. The combined average metastasis rate for both minute and small carcinoids combined (≤ 10 mm) was as high as 10.6% (114 of 1074). The comparative study confirmed that, in both the stomach and the rectum, the metastasis rate of sm carcinoids was significantly higher than that for ordinary sm carcinomas in tumors > 10 mm. Although most patients (92.8%; 1777 of 1914) underwent an endoscopy and/or a wider resection of the lesions, nonresectable metastases were found in 22 patients (1.1%). Of these, 16 had undergone a laparotomy and 6 had not received surgery. Among 1001 patients with GI sm carcinoids, the 5YSRs after curative resection ranged from 98.3% in the rectum to 89.6% in the stomach (P < 0.05), representing an average of 96.7% for the entire series. CONCLUSIONS Unexpectedly high aggressiveness in metastasis rates in both rectal and gastric sm carcinoids > 10 mm exhibiting values significantly higher than those of sm carcinomas were found in 1914 patients suffering from GI sm carcinoids. However, in sm carcinoids at either the minute or small tumor stage (tumors ≦ 10 mm), the metastasis rates were comparable to those of sm carcinomas. It should be emphasized that the 5YSRs for patients with GI sm carcinoids may be comparable to those with sm carcinomas in certain cases. These points should be taken into consideration when treating patients with GI carcinoids, particularly in the early stage, and even with the depth of invasion confined to the submucosa. Cancer 2005. © 2005 American Cancer Society.

Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: A systematic review and individual participant data meta-analysis

Abstract: BACKGROUND: Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and PHQ-9. METHODS: We conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic accuracy. RESULTS: 16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (-0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01). CONCLUSIONS: PHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.

Carcinoids and their variant endocrinomas. An analysis of 11842 reported cases.

Abstract: Endocrinocarcinomas consisting of carcinoids and their variant carcinomas with endocrine features are neoplasms of relatively rare occurrence but have often been reported in many countries and regions of the world. The largest series of 13715 cases from the United States was published in 2003. A total number of 11842 reported cases of endocrinocarcinomas from the Niigata Registry were divided into two groups: the carcinoid group (n = 10804) with the typical (n = 9430) and the atypical (n = 1374) series and the variant group (n = 1038). These cases came from 64 countries and reports were written in 17 different languages. They were statistically evaluated for comparison between the two groups or series in various aspects, including gender and age, tumor-size, rate of metastases, immunohistochemistry, and survival after curative resection. In the carcinoid group, more frequent cases were found in the digestive system (64.2%) than in the extradigestive system (35.8%). Organ distribution of carcinoid cases exhibited the most frequent site to be the respiratory system (19.8%), followed by the rectum (15.0%), jejunoileum (12.0%), stomach (11.4%), appendix (9.6%) and duodenum (8.3%). An extremely small number of cases (less than 0.7%) were found in the middle ear, testicle, kidney, and several others. The highest rate of metastases was noted in the ileocecum (75.3%), followed by the jejunoileum (65.2%), pancreas (64.2%), and larynx (61.4%). Small carcinoids with invasion confined to the mucosa and submucosa, indicated an unexpectedly high metastasis rate of 13.8% for lesions 20 mm or less, and 10.0% for those 10 mm or less, and 6.1% for those 5 mm or less. The carcinoid syndrome was found to occur at the rate of 7.7% of overall 11057 cases reported between 1953 and 2002, with the highest incidence of 28.8% in the 5-year period between 1963 and 1967, gradually decreasing down to 3.7% in the last 5 years. The 5-year survival rate after curative resection of lesions showed a significant difference between the carcinoid group and the variant group (82.0% vs 41.8%: P < 0.0001). In the former group, the 5-year survival rate showed a significant difference between cases with or without metastases (61.4% vs 95.7%: P < 0.0001). In the latter group, the 5-year survival rate was 74.5% for cases without metastases and 24.1% for those with metastases (P < 0.0001). The highest 5-year survival rate in the carcinoid group was noted in the ovary (93.6%), followed by the liver (92.6%), the respiratory system (89.7%), the appendix (89.5%), and the rectum (85.4%), while poor 5-year survival rates were recorded in the pancreas (43.2%), the esophagus (43.5%) and the larynx (47.6%). It should be emphasized that there is a significant statistical difference in many aspects between the carcinoid group and the variant group. The present study confirms that the malignant nature of these endocrine tumors is well reflected in their metastasis rates, even in small lesions with submucosal invasion, resulting in the 5-year survival rates of a significant difference among the groups or series.