South Carolina Department of Health and Environmental Control

About: South Carolina Department of Health and Environmental Control is a government organization based out in Columbia, South Carolina, United States. It is known for research contribution in the topics: Population & Public health. The organization has 334 authors who have published 315 publications receiving 11187 citations.

Determinants of major cardiovascular risk factors among participants of the South Carolina WISEWOMAN program, 2009-2012.

Abstract: Introduction Cardiovascular disease (CVD) is the leading cause of death among US women, accounting for 25% of all deaths in this population. Approximately 65% of these deaths occur in asymptomatic women. Hypertension, hypercholesterolemia, and diabetes mellitus (diabetes) are major risk factors for CVD and can be treated effectively if identified at an early stage. Methods Data were available from 3,572 uninsured first-time female participants aged 40 to 65 years, referred by their health professional to the South Carolina Well-Integrated Screening and Evaluation for Women Across the Nation (SC WISEWOMAN), 2009-2012. All women completed a structured health-risk and behavior questionnaire. Anthropometric measures were recorded and data on clinical risk-factors were collected. Prevalence-ratios (PRs) were obtained by predictive multivariable log-linear modeling. Results The prevalence of risk factors was 34.7% for uncontrolled hypertension, 9.3% for hypercholesterolemia, and 21% for diabetes. Prevalence of untreated hypertension was 15.6%; hypercholesterolemia, 8%; and diabetes, 4%. The greatest significant predictor of hypercholesterolemia was hypertension (PR = 4.37) and vice versa (PR = 2.39). The greatest significant predictors of diabetes were obesity (PR = 2.23), family history of diabetes (PR = 2.02), and hypercholesterolemia (PR = 1.85). Being obese (PR = 1.36), overweight (PR = 1.23), aged 60 years or more (PR = 1.26), and black (PR = 1.14) were significant predictors of having at least one CVD risk factor. Being black (PR = 1.09) was the only significant predictor of having comorbid conditions. Conclusion Prevalence of uncontrolled CVD risk factors was high among participants in the SC WISEWOMAN program. These findings confirm that the program is reaching high-risk women who are in need of interventions to reduce their risk for CVD through lifestyle changes.

A Cluster of Group A Streptococcal Infections in a Skilled Nursing Facility-the Potential Role of Healthcare Worker Presenteeism.

Abstract: Objectives To determine the extent of a group A streptococcus (GAS) cluster (2 residents with invasive GAS (invasive case-patients), 2 carriers) caused by a single strain (T antigen type 2 and M protein gene subtype 2.0 (T2, emm 2.0)), evaluate factors contributing to transmission, and provide recommendations for disease control. Design Cross-sectional analysis and retrospective review. Setting Skilled nursing facility (SNF). Participants SNF residents and staff. Measurements The initial cluster was identified through laboratory notification and screening of SNF residents with wounds. Laboratory and SNF administrative records were subsequently reviewed to identify additional residents with GAS, oropharyngeal and wound (if present) swabs were collected from SNF staff and residents to examine GAS colonization, staff were surveyed to assess infection control practices and risk factors for GAS colonization, epidemiologic links between case-patients and persons colonized with GAS were determined, and facility infection control practices were assessed. Results No additional invasive case-patients were identified. Oropharyngeal swabs obtained from all 167 SNF residents were negative; one wound swab grew GAS that was the same as the outbreak strain (T2, emm 2.0). The outbreak strain was not identified in any of the 162 staff members. One of six staff members diagnosed with GAS pharyngitis worked while ill and had direct contact with invasive case-patients within a few weeks before their onset of symptoms. Additional minor breaches in infection control were noted. Conclusion Sick healthcare workers may have introduced GAS into the SNF, with propagation by infection control lapses. “Presenteeism,” or working while ill, may introduce and transmit GAS to vulnerable in SNF populations. Identification of an invasive GAS case-patient should trigger a prompt response by facilities to prevent further transmission and workplace culture, and policies should be in place to discourage presenteeism in healthcare settings.

Mind the gap: racial differences in breast cancer incidence and biologic phenotype, but not stage, among low-income women participating in a government-funded screening program

Abstract: Breast cancer mortality rates in South Carolina (SC) are 40 % higher among African-American (AA) than European-American (EA) women. Proposed reasons include race-associated variations in care and/or tumor characteristics, which may be subject to income effects. We evaluated race-associated differences in tumor biologic phenotype and stage among low-income participants in a government-funded screening program. Best Chance Network (BCN) data were linked with the SC Central Cancer Registry. Characteristics of breast cancers diagnosed in BCN participants aged 47–64 years during 1996–2006 were abstracted. Race-specific case proportions and incidence rates based on estrogen receptor (ER) status and histologic grade were estimated. Among 33,880 low-income women accessing BCN services, repeat breast cancer screening utilization was poor, especially among EAs. Proportionally, stage at diagnosis did not differ by race (607 cancers, 53 % among AAs), with about 40 % advanced stage. Compared to EAs, invasive tumors in AAs were 67 % more likely (proportions) to be of poor-prognosis phenotype (both ER-negative and high-grade); this was more a result of the 46 % lesser AA incidence (rates) of better-prognosis (ER+ lower-grade) cancer than the 32 % greater incidence of poor-prognosis disease (p values <0.01). When compared to the general SC population, racial disparities in poor-prognostic features within the BCN population were attenuated; this was due to more frequent adverse tumor features in EAs rather than improvements for AAs. Among low-income women in SC, closing the breast cancer racial and income mortality gaps will require improved early diagnosis, addressing causes of racial differences in tumor biology, and improved care for cancers of poor-prognosis biology.

Spatial Bayesian surveillance for small area case event data

Abstract: There has been little development of surveillance procedures for epidemiological data with fine spatial resolution such as case events at residential address locations. This is often due to difficulties of access when confidentiality of medical records is an issue. However, when such data are available, it is important to be able to affect an appropriate analysis strategy. We propose a model for point events in the context of prospective surveillance based on conditional logistic modeling. A weighted conditional autoregressive model is developed for irregular lattices to account for distance effects, and a Dirichlet tessellation is adopted to define the neighborhood structure. Localized clustering diagnostics are compared including the proposed local Kullback-Leibler information criterion. A simulation study is conducted to examine the surveillance and detection methods, and a data example is provided of non-Hodgkin's lymphoma data in South Carolina.