University of Charleston

About: University of Charleston is a education organization based out in Charleston, West Virginia, United States. It is known for research contribution in the topics: Pharmacy & Health care. The organization has 288 authors who have published 357 publications receiving 8241 citations. The organization is also known as: Morris Harvey College & UC.

A Cross-Disciplinary Special Education Preparation Program: An Undergraduate Experimental Model.

Abstract: Imagine that you have departmental responsibility for several teacher education programs at a small independent university in Appalachia. Suppose you are met by a front page newspaper story which describes a dilemma facing superintendents of several school systems. Their unanimous lament is that they are unable to fill certain specialized teaching vacancies occurring in their systems. While this news item is interesting to you, it is not until the following week that your casual consideration turns to close attention. Imagine further that a second news item depicts two despondent mothers bearing witness, for

Vaginal delivery of protein drugs in rats by gene-transformed Lactococcus lactis.

Abstract: A probiotic bacterium, Lactococcus lactis subsp. lactis (L. lactis) transformed with plasmid ss80, which made it capable of synthesizing and secreting β-lactamase, a 29 kDa protein, was used to deliver β-lactamase via vaginal route. The vaginal absorption of β-lactamase in rats was studied when delivered by this L. lactis system and compared to the β-lactamase solution with or without the untransformed L. lactis. The vaginal administration of 1.2 × 10(7), 3 × 10(7), and 8 × 10(7) colony forming units (cfu) of L. lactis resulted in the amount absorbed of 77, 194, and 216 mU, with the respective doses. C(max), mean retention time and mean absorption time of β-lactamase were also increased with the increase in the cfu of L. lactis administered. These results have demonstrated that L. lactis can significantly increase (p < 0.01) the β-lactamase vaginal absorption as compared to the β-lactamase solution, which is probably due to the adhesion of L. lactis to and continuous synthesis and delivery of β-lactamase directly to the vaginal mucosa. In conclusion, transformed normal flora may be an efficient method to deliver protein drugs through the vaginal route.

Efficacy of Deferasirox in Preventing Complications of Iron Overload in the Iron Overloaded Gerbil

Abstract: 55 Introduction 56 Results 57 Characterization of animals 57 Cardiac iron levels 57 Ferritin protein expression 59 Superoxide abundance 60 Protein oxidation 61 Determination of ERK1/2-, p38-, and JNK-MAPK phosphorylation 63 Discussion 64 Deferasirox decreases cardiac iron and ferritin levels in the iron overloaded gerbil 65

THE EFFECT OF DIOXIN ON LOW BIRTH WEIGHT IN SOUTHERN WEST VIRGINIA BETWEEN 1955 to 1969

Abstract: Objective: The effect of low birth weight as a result of dioxin-based exposure has been investigated through the existing literature, but the debate on exact point source and production is still debated. The Monsanto factory located in Nitro, West Virginia produced Agent Orange from 1948 to 1969. Methods: The vital statistics registry from the state of West Virginia of Kanawha county and Putnam county West Virginia. The production of dioxin and 2-4-5T was obtained from the legal files from (Civil Action No. 04-C-465) and the expert witness of Dr. Bruce Bell. In order to understand this relationship a time series analysis was conducted to compare 245T and dioxin and low-birthweight in Kanawha County and Putnam County, West Virginia. Results: The results suggest dioxin within Kanawha county had a suggestive relationship associated with dioxin production and low birthweight from 1948 to 1969 had a suggestive relationship of (p = 0.042). The comparison county of Putnam had no statistically significant relationship between low birthweight and dioxin production (p = 0.203). Agent Orange (2-4-5t) was also considered and measured within the counties of Kanawha and Putnam Counties, within these two counties no statistically significant relationship was observed. Conclusions: In conclusion the association between dioxin and low birthweight still requires more research but this analysis illustrates that there appears to be a suggestive relationship that exists within Kanawha County, West Virginia as related to the production of and effect of the by-product of dioxin.

Mainstreaming kids with reading and writing problems: special challenges of the mathematics classroom

Abstract: This article describes the changes in mathematics classrooms since the National Council of Teachers of Mathematics standards have been proposed and the difficulties those changes pose for students with reading and writing problems These students may have specific learning disabilities, use English as a second language, or have other risk factors such as attention deficits or previous inadequate instruction Specific suggestions are offered for preparing students for mainstreaming into regular math classes and for providing the supports students may need to succeed