Institution
XinHua Hospital
Healthcare•Shanghai, China•
About: XinHua Hospital is a healthcare organization based out in Shanghai, China. It is known for research contribution in the topics: Medicine & Biology. The organization has 908 authors who have published 596 publications receiving 11785 citations.
Topics: Medicine, Biology, Internal medicine, Cancer, Gene
Papers published on a yearly basis
Papers
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TL;DR: IBS is a common and frequently occurring disease in Shanghai Songjiang community and the history of gastrointestinal infection,abdominal surgery, taking antibiotics or analgesics,intake of more spicy food, anxiety and insomnia may be risk factors of IBS.
Abstract: Objective To explore the prevalence,subtype,distribution characteristics and risk factors of IBS met ROME Ⅲ criteria in local adult residents of Shanghai Songjiang area.Methods With multi-stage,stratified cluster random sampling method,from April to May in 2010,residents of45 shanghai Songjiang communities were interviewed by questionnaire survey.IBS diagnosis was based on Rome Ⅲ criteria,and the subtypes were according to Bristol stool scale.Self-rating anxiety scale (SAS),self-rating depression scale (SDS) and Athens insomnia scale (AIS) were also simultaneously finished. Results There were 7648 individuals who completed the survey with qualified questionnaires; the efficient rate was 90%. The sample size accounted about 1.62% of total population in Shanghai Songjiang area.Total 970 patients were detected,who met the Rome Ⅲ criteria,of those 492 males and 478 females.The adjusted prevalence of IBS was 13.1%,13.8% in males and 12.7% in females.The ratio of male to female was 1 ∶ 0.92.There was no significant difference in detection rate between males and females (P>0.05).The prevalence was highest in the 18 to 29 years age group (18.2%,P=0.000).IBS unsubtyped (IBS-U) was the most common type in patients who met the Rome Ⅲ criteria (45.3 %),IBS with diarrhea (IBS-D) type was more common in male (27.0%) and IBS with constipation (IBS-C) was more common in female (19.5%).The IBS prevalence of obesity group (x2 =4.046,P=0.044),higher education group (x2=31.210,P=0.000),mental group (x2 =8.409,P =0.015),unmarried group(x2 =26.933,P =0.000) and no abdominal surgery history group(x2 =5.894,P=0.015) was higher than that of control group.The risk of IBS prevalence in those who had the history of gastrointestinal infection,abdominal surgery,taking antibiotics or analgesics increased by 5.105,3.388,2.949 and 2.811 times respectively(P=0.000).Multivariate analysis indicated that the risk of IBS prevalence was increased by 1.69 times if took more spicy food,however high-protein diet was a protective factor (OR=0.900,P=0.000).Anxiety (OR=2.452,P=0.000) and insomnia (OR=1.923,P=0.000) were also risk factors of IBS.Conclusion IBS is a common and frequently occurring disease in Shanghai Songjiang community.The history of gastrointestinal infection,abdominal surgery,taking antibiotics or analgesics,intake of more spicy food,anxiety and insomnia may be risk factors of IBS.
Key words:
Irritable bowel syndrome; Epidemiologic studies; Reference standards; Protein insoforms; Urban population
4 citations
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TL;DR: The results indicated that plain radiographs often fail to delineate the pathological features of thoracolumbar burst fractures, leading to delay in diagnosis, and burst fractures should be differentiated from compression fractures.
4 citations
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TL;DR: In this paper , the authors proposed a modular multilevel converter (MMC)-based five-terminal medium and low voltage (MV/LV) hybrid AC/DC microgrids.
4 citations
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TL;DR: Blood collection time, smoking status, genetic polymorphism of CYP2C19 and clopidogrel doses were found to affect the plasma concentrations of SR26334 significantly, and explained up to 63.1% of the total variation (adjusted R(2) of 0.631) in the plasma concentration of SR 26334 in Chinese patients.
3 citations
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TL;DR: DGGE is more sensitive than SSCP in screening the mutations of exon 12 of the PAH gene and can be used to define all the mutations, indicating the similarity in the frequency of R413P mutation between northern and southern patients.
Abstract: OBJECTIVE To obtain the mutation spectrum of exon 12 of the phenylalanine hydroxylase(PAH) gene. METHODS The samples from 127 patients with phenylketonuria(PKU) were studied by polymerase chain reaction(PCR)-single strand conformation polymorphism(SSCP) PCR-denaturing gradient gel electrophoresis(DGGE) and direct DNA sequencing. RESULTS Four heterozygous mutations including R413P S411X R408W R408Q in 10 of 127 patients were identified by DNA sequencing. The frequencies of R413P S411X R408W R408Q mutation were 2.76%, 0.39%, 0.39% and 0.39%, respectively. The S411X mutation in Chinese was first reported. Only 2 cases with R413P mutation were detected by SSCP. DGGE analysis showed that 10 cases displayed 3 kinds of abnormal electrophoretic bands. There were no obvious differences in the frequency of R413P mutation between northern and southern Chinese with PKU, and between classical PKU and hyperphenylalaninemia. CONCLUSION DGGE is more sensitive than SSCP in screening the mutations of exon 12 of the PAH gene. DGGE combined with DNA sequencing can be used to define all the mutations of exon 12 of the PAH gene. These results indicate the similarity in the frequency of R413P mutation between northern and southern patients.
3 citations
Authors
Showing all 969 results
Name | H-index | Papers | Citations |
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Qian Wang | 108 | 2148 | 65557 |
Lin Li | 104 | 2027 | 61709 |
Tao Chen | 86 | 820 | 27714 |
Bo Li | 83 | 891 | 28722 |
Jun Zhang | 63 | 424 | 19149 |
Tingting Tang | 56 | 256 | 10045 |
Wei Yao | 53 | 241 | 9033 |
Yingbin Liu | 38 | 179 | 4538 |
Lei-Sheng Jiang | 36 | 84 | 3558 |
Zhenan Zhu | 35 | 118 | 3588 |
Li-Yang Dai | 34 | 69 | 3174 |
Maolan Li | 32 | 127 | 3084 |
Xiang-Yang Wang | 30 | 213 | 3316 |
Yuhong Chen | 30 | 149 | 3038 |
Qiang Wu | 29 | 75 | 4203 |