XinHua Hospital

About: XinHua Hospital is a healthcare organization based out in Shanghai, China. It is known for research contribution in the topics: Medicine & Biology. The organization has 908 authors who have published 596 publications receiving 11785 citations.

Large primary liver cancer treated by chemoembolization combined with radiotherapy successfully.

Abstract: For unresectable primary liver cancer, transcatheter arterial chemoembolization is the most effective method in reducing the size of tumor and become the most popular forms in Asia, but, it is not a curative approach and additional therapy is needed to kill the residual tumor cells. In this paper, we report a case in which a patient with a single very large liver cancer has been successfully treated by chemoembolization combined with radiotherapy. The results suggest that this is a very promising therapeutic approach for single large primary liver cancer.

[Arrhythmia in the long-term follow-up after intracardiac repair of tetralogy of Fallot].

Abstract: Objective The long-term success of intracardiac repair of tetralogy of Fallot is hampered by the occurrence of arrhythmias The aim of the present study was to determine the incidence of arrhythmias after intracardiac repair of tetralogy of Fallot and their correlation with surgical and clinical findings Methods The study group consisted of 54 patients, 35 males and 19 females They underwent repair at a mean age of 51 months (range 17 to 117 months) The median age at the time of study was 9 4 years (range 5 to 14 years), and the mean duration of follow-up was 4 3 years (range 2 8 to 9 0 years) after surgery The follow-up study included routine ECG, 24 hour Holter, echocardiography and exercise testing Results The incidence of ventricular arrhythmia was 33 percent, and 1 patient had non-sustained ventricular tachycardia All patients with elevated right ventricular pressure had ventricular arrhythmias, and 28% of patients with normal right ventricular pressure had ventricular arrhythmias (P0 05) 53% of patients had significant ventricular arrhythmias when the duration of cardiopulmonary bypass was ≥90 minutes, as opposed to 23% when it was 90 minutes (P0 05) There was no significant difference in prevalence of ventricular arrhythmias between mild pulmonary regurgitation and severe pulmonary regurgitation (21% vs 40%,P0 05) No significant difference was found in the incidence of ventricular arrhythmias between follow-up in five years and more than five years (32% vs 34%,P0 05) Age at surgery correlated with the prevalence of ventricular arrhythmias (r=-0 221, P0 05) Eight patients (15%) had supraventricular arrhythmias Conclusion The frequency of ventricular arrhythmias correlated with elevated right ventricular systolic pressure, the duration of cardiopulmonary bypass, and the age at surgery No correlation was found between pulmonary regurgitation and the duration of follow-up Exercise-induced frequent multiform premature ventricular complexes were associated with abnormal hemodynamic status and high risk of ventricular tachycardia

[Application of CD34+ autologous peripheral progenitor cell transplant in the treatment of children with refractory SLE].

Abstract: Objective Systematic lupus erythematosis (SLE) is a severe disease which affects the patient for many years and there is no radical cure for the disease To explore a possible way to treat children with refractory SLE, the authors treated 2 children with grade III and IV lupus nephropathy for 5 years and 7 years respectively, mainly presented with persistent thrombocytopenia, proteinuria, pleural effusion with CD34(+) autologous peripheral progenitor cells transplantation Methods Mobilized with G-CSF and collected with CS-3000 Cell Separator, passed through the CliniMacs CD34(+) cell selection device, the count of CD34(+) cells obtained reached 10 x 10(6)/kg and 17 x 10(6)/kg, respectively with the remaining of 20 x 10(5)/kg and 10 x 10(4)/kg of CD3(+) cells individually The selected CD34(+) cells were frozen at -80 degrees C The conditioning regimen consisted of cyclophosphamide [50 mg/(kg x day) for 4 days] plus ATG [Fresennius S 5 mg/(kg x day) for 3 days] After 48 h treatment with cyclophosphamide, the frozen stem cells were infused back to the patients Results Neutrophils recovered on 9 and 7 days after transplantation respectively in these 2 cases Beginning from 15 days, the platelet count recovered and remained at over 100 x 10(9)/L The sign of Cushing's syndrome disappeared completely 3 months after transplantation because discontinuing the steroid One child's height had a 5 cm increase within 6 months after stopping steroid and this was the first height gain during the 7 years since she had had the disease Till this paper was written, these 2 children were followed up for 13 months and 6 months, respectively, all the original symptoms and autoantibodies related to autoimmune disorders disappeared But the cell-mediated immunity did not recover yet with the CD4(+) cell level still remained at a lower level Conclusion The effect of CD34(+) autologous peripheral progenitor cell transplantation on the children with refractory SLE was satisfactory so far, but the long-term effect remains to be confirmed by further studies on more cases

Development and Clinical Validation of Semi-Supervised Generative Adversarial Networks for Detection of Retinal Disorders in Optical Coherence Tomography Images Using Small Dataset

Abstract: To develop and test semi-supervised generative adversarial networks (GANs) that detect retinal disorders on optical coherence tomography (OCT) images using a small-labeled dataset.From a public database, we randomly chose a small supervised dataset with 400 OCT images (100 choroidal neovascularization, 100 diabetic macular edema, 100 drusen, and 100 normal) and assigned all other OCT images to unsupervised dataset (107,912 images without labeling). We adopted a semi-supervised GAN and a supervised deep learning (DL) model for automatically detecting retinal disorders from OCT images. The performance of the 2 models was compared in 3 testing datasets with different OCT devices. The evaluation metrics included accuracy, sensitivity, specificity, and the area under the receiver operating characteristic curves.The local validation dataset included 1000 images with 250 from each category. The independent clinical dataset included 366 OCT images using Cirrus OCT Shanghai Shibei Hospital and 511 OCT images using RTVue OCT from Xinhua Hospital respectively. The semi-supervised GANs classifier achieved better accuracy than supervised DL model (0.91 vs 0.86 for local cell validation dataset, 0.91 vs 0.86 in the Shanghai Shibei Hospital testing dataset, and 0.93 vs 0.92 in Xinhua Hospital testing dataset). For detecting urgent referrals (choroidal neo-vascularization and diabetic macular edema) from nonurgent referrals (drusen and normal) on OCT images, the semi-supervised GANs classifier also achieved better area under the receiver operating characteristic curves than supervised DL model (0.99 vs 0.97, 0.97 vs 0.96, and 0.99 vs 0.99, respectively).A semi-supervised GAN can achieve better performance than that of a supervised DL model when the labeled dataset is limited. The current study offers utility to various research and clinical studies using DL with relatively small datasets. Semi-supervised GANs can detect retinal disorders from OCT images using relatively small dataset.