Institution
XinHua Hospital
Healthcare•Shanghai, China•
About: XinHua Hospital is a healthcare organization based out in Shanghai, China. It is known for research contribution in the topics: Medicine & Biology. The organization has 908 authors who have published 596 publications receiving 11785 citations.
Topics: Medicine, Biology, Internal medicine, Cancer, Gene
Papers published on a yearly basis
Papers
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Inova Health System1, Inova Fairfax Hospital2, University of the Philippines3, Saga University4, Marmara University5, Saga Group6, Helwan University7, Hebron University8, First Affiliated Hospital of Wenzhou Medical University9, XinHua Hospital10, Kaohsiung Medical University11, The Chinese University of Hong Kong12, King Saud University13, University of Malaya14, National Autonomous University of Mexico15, University of Padua16, University of Turin17, Post Graduate Institute of Medical Education and Research18, University of Sydney19, National and Kapodistrian University of Athens20, Aga Khan University21, University of Paris22, Pontifical Catholic University of Chile23, University of Seville24
TL;DR: In this article, the authors assessed NAFLD knowledge and associated factors among physicians of different specialties globally and found that despite rapidly increasing nonalcoholic fatty liver disease (NAFLD) prevalence, providers' knowledge may be limited.
30 citations
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TL;DR: It was revealed that selenium decreased the EMT events of peritoneal mesothelial cells via inhibition of PI3k/AKT pathways, enabling a better understanding of the mechanism of peritonal fibrosis and explore a new idea for the prevention and treatment.
Abstract: Peritoneal fibrosis resulting from long-term clinical peritoneal dialysis has been the main reason of dropout from peritoneal dialysis. Peritonitis as a common complication of peritoneal dialysis treatment may lead to the occurrences of peritoneal fibrosis. We cultured peritoneal mesothelial cells with lipopolysaccharides (LPS) in order to stimulate the environment of peritonitis and investigate whether lipopolysaccharides could induce epithelial-to-mesenchymal transition (EMT). Oxidative stress could stimulate fibrogenesis while selenium has antioxidant properties. So, this study also explored whether selenium supplementation affects lipopolysaccharide-induced EMT and fibrosis. We found that lipopolysaccharides could activate EMT changes such as the loss of E-cadherin and the increase of α-smooth muscle actin (α-SMA), collagen I, vimentin, and fibronectin (FN), while selenium inhibits EMT by modulating reactive oxygen species (ROS) generation and ROS/MMP-9 signaling pathways in peritoneal mesothelial cells. Moreover, it was revealed that selenium decreased the EMT events of peritoneal mesothelial cells via inhibition of PI3k/AKT pathways. In conclusion, these findings enable a better understanding of the mechanism of peritoneal fibrosis and explore a new idea for the prevention and treatment.
30 citations
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TL;DR: It is reported that TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), plays an essential role in placental trophoblast fusion by translocating PS to cell surface independent of apoptosis, providing insight into understanding cell-cell fusion mechanism of other cell types and on mitigating pregnancy complications such as miscarriage, intrauterine growth restriction, and preeclampsia.
Abstract: Cell-cell fusion or syncytialization is fundamental to the reproduction, development, and homeostasis of multicellular organisms. In addition to various cell type-specific fusogenic proteins, cell surface externalization of phosphatidylserine (PS), a universal eat-me signal in apoptotic cells, has been observed in different cell fusion events. Nevertheless, the molecular underpinnings of PS externalization and cellular mechanisms of PS-facilitated cell-cell fusion are unclear. Here, we report that TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), plays an essential role in placental trophoblast fusion by translocating PS to cell surface independent of apoptosis. The placentas from the TMEM16F knockout mice exhibit deficiency in trophoblast syncytialization and placental development, which lead to perinatal lethality. We thus identified a new biological function of TMEM16F CaPLSase in trophoblast fusion and placental development. Our findings provide insight into understanding cell-cell fusion mechanism of other cell types and on mitigating pregnancy complications such as miscarriage, intrauterine growth restriction, and preeclampsia.
29 citations
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Wellcome Trust Centre for Human Genetics1, Zhengzhou University2, XinHua Hospital3, Shanxi Medical University4, China Medical University (PRC)5, Shanghai Mental Health Center6, Capital Medical University7, Sun Yat-sen University8, Jiangsu University9, Harbin Medical University10, Hebei Medical University11, Chongqing Medical University12, Sichuan University13, Lanzhou University14, Shantou University15, Tongji University16, Jinan University17, Wuhan University18, Tianjin First Center Hospital19, Clinical Trial Service Unit20, Virginia Commonwealth University21
TL;DR: Significantly more episodes of MDD occur among those with lower educational attainment (rather than longer episodes of disease), consistent with the hypothesis that the lower socioeconomic position increases the likelihood of developing MDD.
Abstract: Background
The prevalence of major depressive disorder (MDD) is higher in those with low levels of educational attainment, the unemployed and those with low social status. However the extent to which these factors cause MDD is unclear. Most of the available data comes from studies in developed countries, and these findings may not extrapolate to developing countries. Examining the relationship between MDD and socio economic status in China is likely to add to the debate because of the radical economic and social changes occurring in China over the last 30 years.
Principal findings
We report results from 3,639 Chinese women with recurrent MDD and 3,800 controls. Highly significant odds ratios (ORs) were observed between MDD and full time employment (OR = 0.36, 95% CI = 0.25–0.46, logP = 78), social status (OR = 0.83, 95% CI = 0.77–0.87, logP = 13.3) and education attainment (OR = 0.90, 95% CI = 0.86–0.90, logP = 6.8). We found a monotonic relationship between increasing age and increasing levels of educational attainment. Those with only primary school education have significantly more episodes of MDD (mean 6.5, P-value = 0.009) and have a clinically more severe disorder, while those with higher educational attainment are likely to manifest more comorbid anxiety disorders.
Conclusions
In China lower socioeconomic position is associated with increased rates of MDD, as it is elsewhere in the world. Significantly more episodes of MDD occur among those with lower educational attainment (rather than longer episodes of disease), consistent with the hypothesis that the lower socioeconomic position increases the likelihood of developing MDD. The phenomenology of MDD varies according to the degree of educational attainment: higher educational attainment not only appears to protect against MDD but alters its presentation, to a more anxious phenotype.
29 citations
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TL;DR: Results suggest that tetrandrine at lower concentrations has a significant inhibiting effect on culture-activation and TGF-beta(1)-stimulated activation of rat HSCs, and that it may be due to an up-regulation of Smad 7 which in turn blocks T GF- beta(1) expression and its downstream signaling.
29 citations
Authors
Showing all 969 results
Name | H-index | Papers | Citations |
---|---|---|---|
Qian Wang | 108 | 2148 | 65557 |
Lin Li | 104 | 2027 | 61709 |
Tao Chen | 86 | 820 | 27714 |
Bo Li | 83 | 891 | 28722 |
Jun Zhang | 63 | 424 | 19149 |
Tingting Tang | 56 | 256 | 10045 |
Wei Yao | 53 | 241 | 9033 |
Yingbin Liu | 38 | 179 | 4538 |
Lei-Sheng Jiang | 36 | 84 | 3558 |
Zhenan Zhu | 35 | 118 | 3588 |
Li-Yang Dai | 34 | 69 | 3174 |
Maolan Li | 32 | 127 | 3084 |
Xiang-Yang Wang | 30 | 213 | 3316 |
Yuhong Chen | 30 | 149 | 3038 |
Qiang Wu | 29 | 75 | 4203 |