Journal•ISSN: 0065-2326
Advances in Cardiology
Karger Publishers
About: Advances in Cardiology is an academic journal. The journal publishes majorly in the area(s): Myocardial infarction & Coronary artery disease. It has an ISSN identifier of 0065-2326. Over the lifetime, 715 publications have been published receiving 7925 citations.
Topics: Myocardial infarction, Coronary artery disease, Framingham Risk Score, Rehabilitation, Heart failure
Papers published on a yearly basis
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TL;DR: Both type I and type II diabetes are powerful and independent risk factors for coronary artery disease (CAD), stroke, and peripheral arterial disease.
Abstract: Both type I and type II diabetes are powerful and independent risk factors for coronary
artery disease (CAD), stroke, and peripheral arterial disease. Atherosclerosis accounts for
virtually 80% of a
293 citations
TL;DR: The identification of OSA may be a difficult task for the clinician, even in populations in which OSA is highly prevalent such as patients with cardiovascular disorders because they may not present the cardinal signs of the disease, e.g. excessive sleepiness and obesity.
Abstract: Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete and partial obstructions of the upper airway during sleep. The diagnosis of OSA requires the objective demonstration o
182 citations
139 citations
TL;DR: In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.
Abstract: The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle). These functions have special requirements regarding electrical coupling and, therefore, expression of connexin isoforms. Electrical coupling in the center of the SAN should be weak to protect it from the inhibitory electrotonic influence of the more hyperpolarized non-pacemaking atrial muscle surrounding the SAN. However, for the SAN to be able to drive the atrial muscle, electrical coupling should be strong in the periphery of the SAN. Consistent with this, in the center of the SAN there is no expression of Cx43 (the principal connexin of the working myocardium) and little expression of Cx40, but there is expression of Cx45 and Cx30.2, whereas in the periphery of the SAN Cx43 as well Cx45 is expressed. In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.
136 citations
136 citations