J
James O. Tellez
Researcher at University of Manchester
Publications - 31
Citations - 1985
James O. Tellez is an academic researcher from University of Manchester. The author has contributed to research in topics: Sinoatrial node & Electrical conduction system of the heart. The author has an hindex of 19, co-authored 31 publications receiving 1785 citations.
Papers
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Journal ArticleDOI
Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker
N.J. Chandler,I.D. Greener,James O. Tellez,Shin Inada,Hanny Musa,Peter C. M. Molenaar,Dario DiFrancesco,Mirko Baruscotti,Renato Longhi,Robert H. Anderson,Rudolf Billeter,Vinod Sharma,Daniel C. Sigg,Mark R. Boyett,Halina Dobrzynski +14 more
TL;DR: Ion channels show a complex and heterogeneous pattern of expression in the SN, paranodal area, and RA in humans, and the expression pattern is appropriate to explain pacemaking.
Journal ArticleDOI
Computer Three-Dimensional Reconstruction of the Sinoatrial Node
Halina Dobrzynski,Jue Li,James O. Tellez,I.D. Greener,Vladimir P. Nikolski,Sally Wright,Simon H. Parson,Sandra C. Jones,Matthew K. Lancaster,Mitsuru Yamamoto,Haruo Honjo,Yoshiko Takagishi,Itsuo Kodama,Igor R. Efimov,Rudolf Billeter,Mark R. Boyett +15 more
TL;DR: For the first time, a 3D anatomically detailed mathematical model of the sinoatrial node has been constructed, and this shows the presence of a specialized interface between the SAN and atrial muscle.
Journal ArticleDOI
Distribution and Functional Characterization of Equilibrative Nucleoside Transporter-4, a Novel Cardiac Adenosine Transporter Activated at Acidic pH
Kay Barnes,Halina Dobrzynski,Sophie Foppolo,Paul R. Beal,Fouzia Ismat,Elspeth R. Scullion,Lijie Sun,James O. Tellez,Mabel W.L. Ritzel,William C. Claycomb,Carol E. Cass,James D. Young,Rudi Billeter-Clark,Mark R. Boyett,Stephen A. Baldwin +14 more
TL;DR: It is hypothesized that ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia.
Journal ArticleDOI
Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit
James O. Tellez,Halina Dobrzynski,I.D. Greener,Gillian M. Graham,Emma Laing,Haruo Honjo,Simon J. Hubbard,Mark R. Boyett,Rudi Billeter +8 more
TL;DR: Quantification of individual transcripts showed that there are significant differences in the abundance of 63% of the transcripts studied between the SAN and atrial Muscle, and cluster analysis showed that the transcript profile of the SAN is significantly different from that of atrial muscle.
Book ChapterDOI
Connexins in the sinoatrial and atrioventricular nodes.
Mark R. Boyett,Shin Inada,Shin Yoo,Jue Li,Jie Liu,James O. Tellez,I.D. Greener,Haruo Honjo,Rudolf Billeter,Ming Lei,Henggui Zhang,Igor R. Efimov,Halina Dobrzynski +12 more
TL;DR: In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.