Showing papers in "Advances in Enzyme Regulation in 1965"

TL;DR: It is suggested that spontaneous oscillatory behavior in an organism's control processes constitutes the dynamic basis of rhythmic behavior patterns in plant and animal physiology.

TL;DR: It was found by sucrose gradient centrifugation studies that the enzyme sediments more slowly in the presence of palmityl-CoA than in its absence, which might represent a negative feedback mechanism in the cellular regulation of fatty acid synthesis.

TL;DR: A mechanism is suggested which is similar in nature to the activation and inactivation of actomyosin (and perhaps of phosphorylase b kinase) by Ca++ ions which could explain the results summarized above.

TL;DR: It has been proposed that glucocorticoid induction of transaminase activity may result in sequential expansion in the routes of amino nitrogen transport, leading to the observed enhancement in purine nucleotide biosynthesis—“purinoneogenesis”—as well as gluconeogenesis and increased urea output, all of which are characteristic of the cortisonized animal.

TL;DR: Fructokinase also develops after birth in both fructogenic and non-fructogenic species and this may represent another example of development of an enzyme in response to hormonal changes occurring as a result of parturition.

TL;DR: Fractionation and characterization of the pulse-labeled RNA from livers of rats treated with hydrocortisone demonstrates that the hormone increases the synthesis of ribosomal and transfer RNA as well as a DNA-like RNA.

TL;DR: Colchicine is as effective as actinomycin at 13 days, and at 9 days is also as efficacious as the antibiotic in the presence or absence of hydrocortisone, and the effects of hormone and antibiotic are additive.

TL;DR: Evidence has been summarized which establishes that the increase in rat liver glutamic-alanine transaminase activity consequent to glucocorticoid administration is a reflection of an increased tissue level of normal type enzyme.

TL;DR: Changes observed during development in the levels of various enzymes concerned with carbohydrate metabolism indicate a decrease in capacity for glucose utilization and glycolysis and an increase incapacity for glycogenolysis, glucose formation, and lactate utilization.

TL;DR: Neither cortisone nor aspartate induced as partate aminotransferase activity in the Dunning, Novikoff or Morris 5123-D hepatomas, and Puromycin prevented induction of enzyme activity by cortis one to the extent of about 70–80 per cent and completely abolished enzyme induction by aspartates.

TL;DR: It appeared that, at least with the five hepatomas studied here, the “anionic” to the ”cationic” GOT ratio was higher in the hepatomas than in the normal.

TL;DR: Recent observations demonstrate that cortisol administration causes a rapid rise in production of messenger RNA and it is thought that this may be the basic step which leads to increased enzyme synthesis, an attractivehypothesis.

TL;DR: The experiments suggest that both vitamin E deficiency and glucocorticoids may amplify the primary cytotoxic effect by rendering the coupling less tight between components of the detoxicating enzyme system in the endoplasmic membranes.

TL;DR: The various biochemical parameters and metabolic responses were correlated with the growth rate of hepatomas and there was a failure of response in these biochemical parameters in the kidney cortex.

TL;DR: The nature of the association between changes in the character and intensity of protein synthesis and in amino acid transport activity, as illustrated by these two cases, is discussed.

TL;DR: Both triamcinolone and puromycin appear to inhibit protein synthesis in liver slices and their effects are additive.

TL;DR: Observations are interpreted as indicating that the normal transfer of amylase from the liver to the blood is an active process dependent on the formation of ATP.