Showing papers in "Bioactive Materials in 2023"

TL;DR: A defect self-assembly-enabled metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer was designed and fabricated in this article .

TL;DR: In this paper , the human skeletal muscle-specific ssDNA aptamers (HSM01, etc.) were selected and identified with Systematic Evolution of Ligands by Exponential Enrichment (SELEX).

TL;DR: In this paper , an ultra-small Tungsten-based nanodots (TWNDs) with strong ROS scavenging can be very effective for treatment of acute kidney injury (AKI).

TL;DR: A review of the most recent strategies in development for actively targeted liposomal drug delivery systems for surface, transmembrane and internal cell receptors, enzymes, direct cell targeting and dual-targeting of breast cancer and breast cancer-associated cells, e.g., cancer stem cells, cells associated with the tumor microenvironment, etc. as discussed by the authors .

TL;DR: In this paper , a peptide CAQK-modified siRNA-loaded extracellular vesicle (C-EVs-siRNA) was used for spinal cord injury (SCI) treatment.

TL;DR: A review of hydrogel-related mandibular tissue engineering can be found in this paper , with an update on the advanced fabrication of advanced hydrogels with improved mechanical property, antibacterial ability, injectable form, and 3D bioprinted hydrogEL constructs.

TL;DR: In this paper , a multilayer-structured bioactive glass nanopowder (BGN@PTE) is developed by coating the poly-tannic acid and ε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds.

TL;DR: In this paper , a poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded with magnesium hydride (MgH2) (MN-Mg H2) is manufactured for defeating diabetic wounds.

TL;DR: In this paper , a review of surface characteristics of Ti materials and various conventional surface modification techniques involving mechanical, physical and chemical treatments based on the formation mechanism of the modified coatings is presented.

TL;DR: In this paper , vancomycin (Van) was encapsulated into poly(lactic co-glycolic acid) (PLGA) microspheres through the double emulsion method, which were then loaded into the additively-manufactured porous tantalum (AM-Ta) through gelatin methacryloyl (GelMA) hydrogel to produce the composite Ta/Gel/PLGA/vancomycin(Van) scaffolds for repairing IBDs.

TL;DR: In this paper , the authors explored how proinflammatory signals affect the dose-dependent osteogenic potential of BMP-2, and they observed that the expression level of local IL-1β did not increase with the dose of Bmp-2 in the mouse osteogenesis model.

TL;DR: In this article , an enzyme-sensitive polymeric conjugate, pOEGMA-b-p(GFLG-Dendron-Ppa) (GPLG-DP/Lap NPs) was constructed for ROS therapy and Lapatinib (Lap) for molecular targeted therapy.

TL;DR: In this article , integrin-targeting micellar gemcitabine and paclitaxel (ATN-mG/P, ATN sequence: Ac-PhScNK-NH2) cooperating with polymersomal CpG (NanoCpG) effectively treated TNBC.

TL;DR: In this paper , the authors reported the facile synthesis of antimicrobial dynamic covalent nano-networks (aDCNs) composing antibiotics bearing multiple primary amines, polyphenols, and a crosslinker acylphenylboronic acid.

TL;DR: In this article , a microfluidic chemostatic bioreactor was presented, providing low-bioadhesive cultivations for algae in a cooperative environment of gas, nutrition, and temperature (GNT) involved with high throughput.

TL;DR: In this article , a 3D dynamic hydrogel using magneto-stimulation for direct mesenchymal stem cell (MSC) manufacturing to therapy was proposed, and the authors found that dynamic mechanical stimulation enhanced matrix-integrin β1 interactions which induced MSCs spreading and proliferation.

TL;DR: In this paper , an electroconductive hydrogels (ECHs) loaded with BMSCs-Exos (ECH-ExOS) was used to treat diabetic peripheral nerve injury (PNI) to achieve functional recovery and pain relief.

TL;DR: In this paper , the gold nanoparticles-embedded ceria nanoparticles (Au/CeO2) with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced reactive oxygen species (ROS).

TL;DR: In this paper , a 3D-printed bioscaffold composed of mesoporous bioactive glass nanoparticles (Sr-MBGNs) and gelatin methacrylate (GelMA) is used to reconstruct the extracellular matrix of diabetic patients.

TL;DR: In this article , living nerve-like fibers are prepared via extrusion-based 3D bioprinting for spinal cord injury (SCI) therapy, comprised of neural stem cells embedded within a designed hydrogel that mimics the extracellular matrix (ECM), assembled into a highly spatial ordered architecture, similar to densely arranged bundles of the nerve fibers.

TL;DR: In this article , the 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-methoxy (DMPE)-PEG-conjugated anti-coagulant bivalirudin (DPB) and DMPE-PEG conjugated endothelial progenitor cell (EPC)-binding TPS-peptide (DPT) modifications possessed functionality conducive to promoting vascular graft patency.

TL;DR: The bone/cartilage organoid on-chip (BCoC) as discussed by the authors system is a novel platform of multi-tissue which faithfully emulate the essential elements, biologic functions and pathophysiological response under real circumstances.

TL;DR: In this article , a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles (pSiNPs) as a therapeutic nano-platform to overcome Alzheimer's disease was disclosed.

TL;DR: Wang et al. as discussed by the authors designed H2O2-responsive polymer prodrug NPs with GSH-scavenger (Ce6@P(EG-a-CPBE) NPs) for chemo-photodynamic synergistic cancer therapy.

TL;DR: In this article , an engineered macrophage-biomimetic versatile nanoantidote was developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition suppression.

TL;DR: In this paper , a hybrid biocomposite based on poly(p-dioxanone) (PDO), poly(lactide-co-caprolactone) and silk was developed to produce high-performance grafts suitable for ACL tissue repair.

TL;DR: In this article , a pre-gel state before photo-crosslinking was introduced, where increased viscosity and decreased fluidity allowed the gel to remain in a semi-solid condition.

TL;DR: In this paper , a 3D printed porous multilayer scaffold based on cold-water fish skin gelatin for osteoarticular cartilage regeneration was presented, which can mimic the structure of the original cartilage network in a way that allows chondrocytes to adhere, proliferate and communicate with each other, transport nutrients, and prevent further damage to the joint.

TL;DR: In this paper , a high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin (ZOG) is designed as a multifunctional nucleic acid delivery platform.