Showing papers in "Biomedicine & Pharmacotherapy in 2022"

TL;DR: In this article, a review of the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in-vitro, in vivo and human observations, as well as existing suggestions.

TL;DR: In this paper , a review of the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions.

TL;DR: In this paper , the authors highlighted major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents.

TL;DR: In this paper , the authors present pharmacological activities of different species of edible and medicinal mushrooms and provide tangible evidence that these mushrooms are an excellent source of natural constituents and antioxidants with potential application in pharmaceuticals and in treating and managing different diseases.

TL;DR: In this paper , the authors discuss about the various properties of metallic nanoparticles and their applications in cancer imaging and therapeutics, and the associated bottlenecks related to their clinical translation are also discussed.

TL;DR: The AMP-activated protein kinase (AMPK) is an energy sensor with aberrant expression in various diseases including cancer, cardiovascular diseases and DM as mentioned in this paper , which can lead to development of DM and related complications.

TL;DR: Nanocarriers have been extensively studied and employed for cancerous therapeutic strategies since nanomaterials potentially play a significant role in medical transportation as mentioned in this paper , such as excellent reliability, bioactivity, improved penetration and retention impact, as well as precise targeting and administering.

TL;DR: In this article , the complex physiopathology of oxidative stress in CVD occurrence and novelties regarding the phenomenon are discussed. But, the authors do not consider the effect of specific pathways on the outcome of CVD.

TL;DR: In this paper , the authors summarized the extraction, separation, purification, structure, activity and modification of Radix astragali polysaccharide (RAP) and discussed the structure and activity of RAP.

TL;DR: A growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens as discussed by the authors .

TL;DR: In this article , the authors present an updated summary of the chemical composition of EOs, their current applications in cancer treatments based on clinical studies, and the mechanism of action against the cancer cell lines.

TL;DR: The Omicron variant has been identified as a highly modified, contagious, and crucial variant among the five VOCs of SARS-CoV-2 in the COVID-19 pandemic as mentioned in this paper .

TL;DR: In this paper , the authors summarize the roles and mechanisms of the gut microbiota's composition and metabolite changes in the gut play in obesity and obesity related diseases, and discuss potential therapeutic treatments that can be used to modulate the gut microbiome composition and target the relevant metabolic pathways.

TL;DR: In this paper , the authors provided an in-depth examination of CAR-T cell therapy and its success and failure as a cancer treatment approach, and discussed combination therapies with CAR T Cell.

TL;DR: In this article , the anti-viral potential of selected promising natural products was investigated in the context of therapeutic uses of phytoconstituents and their mechanism of action published in various reputed peer-reviewed journals.

TL;DR: In this paper , the authors reviewed the recent advances in natural compounds from medicinal herbs that possess the bioactivities of simultaneously promoting neuroprotection (e.g., excitotoxicity, oxidative stress, apoptosis, inflammation, and autophagy) and neurorestoration following brain ischemia injury.

TL;DR: The role of natural polyphenols in regulating various cell signaling pathways related to oxidative stress and inflammation has also been reviewed in this paper , revealing the vital role of polyphenol in the prevention and treatment of depressive disorder.

TL;DR: In 2019, the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) separately developed a categorization system for differentiating new strains of SARS-CoV-2 into variants of concern and variants of interest as mentioned in this paper .

TL;DR: In this article , the authors examined numerous manuscripts indexed in the Web of Science database using the VOSviewer software to provide through statistical interpretation of the data a comprehensive description of RA pharmacotherapy in terms of scientific impact, current state of research, number and frequency of citations, most prolific journals, authors, along with their relationships and other useful data for the literature search/publication process.

TL;DR: In this paper , TNFα activated the Na+/H+ exchanger (NHE) and raised cytoplasmatic Na+ ([Na+]c), which increased [Na+],c causes reactive oxygen species (ROS) production, and empagliflozin (EMPA) reduces inflammation-induced ROS through NHE inhibition and lowering of [Na+,]c in human endothelial cells.

TL;DR: In this article , the authors discuss the promising application of RNA-dependent RNA polymerase (RdRp) inhibitors, previously approved or currently being tested in human clinical trials, in the treatment of RNA virus infections.

TL;DR: In this paper , a review of SARS-coronavirus-2 pathophysiology and evolution approaches in altered transmission platforms and how they influence the virus characteristics is presented.

TL;DR: In this article , the authors provided the updated information on all the repurposed drugs candidates for breast cancer with the molecular mechanism responsible for their anti-tumor activity and discussed all the challenges that occur during the drug repurposing process.

TL;DR: In this article , a review mechanistically provides an overview of the neuropathological roles of sustained neuroinflammatory response in the development of depression and elucidates the therapeutic potential of flavonoid and non-flavonoid polyphenols in modulating inflammatory mediators and signaling cascades as well as promoting other neurophysiological and neuroprotective functions underlying inflammation-associated depressive symptoms.

TL;DR: In this article , a comprehensive review of microbial metabolites that are protective or causative for Type 2 diabetes mellitus (T2DM) is provided, including some amino acids-derived metabolites, short-chain fatty acids, trimethylamine N-oxide, and bile acids.

TL;DR: In this paper , the authors assessed the reactogenicity and immunogenicity of COVID-19 vaccination regimens in clinical trials and observational studies and found that the vaccine administration showed a trend toward more frequent systemic reactions.

TL;DR: Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants as discussed by the authors .

TL;DR: Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants.

TL;DR: The NATs are known to concordantly and discordantly regulate gene expression in both cis and trans manners at the transcriptional, post-transcriptional, translational, and epigenetic levels.

TL;DR: In this article , the anti-microbial and cytotoxic efficacies of silver nanoparticles (AgNPs) synthesized with the shrub Lycium shawii were determined.