Showing papers in "Clinical Toxicology in 1973"
TL;DR: In this paper, the authors discuss Hyperkalemia in Acute Digitalis Poisoning: Prognostic Significance and Therapeutic implications, and propose a method to diagnose hyperkalence in acute digitalis poisoning.
Abstract: (1973). Hyperkalemia in Acute Digitalis Poisoning: Prognostic Significance and Therapeutic implications. Clinical Toxicology: Vol. 6, No. 2, pp. 153-162.
141 citations
TL;DR: In this paper, the relationship of Dietary Selenium Concentration, Chemical Cancer Induction, and Tissue Concentration of Selenium in Rats was investigated in the context of rats.
Abstract: (1973). Relationship of Dietary Selenium Concentration; Chemical Cancer Induction; and Tissue Concentration of Selenium in Rats. Clinical Toxicology: Vol. 6, No. 3, pp. 487-495.
75 citations
TL;DR: The properties of 3,4-Methylenedioxyamphetamine, as well as its abuse potential, are described in detail in this review of the literature.
Abstract: (1973). The Properties of 3,4-Methylenedioxyamphetamine (MDA). I. A Review of the Literature. Clinical Toxicology: Vol. 6, No. 1, pp. 45-52.
34 citations
TL;DR: Two experiments using adult female sheep were conducted to investigate the behavioral toxicologic effects of oral doses of lead and there was no significant difference between the number of pedal responses of the control versus low lead and or control versus high lead.
Abstract: Two experiments using adult female sheep were conducted to investigate the behavioral toxicologic effects of oral doses of lead. Eight sheep were trained to depress a pedal following the presentation of an auditory signal. Four sheep were dosed with 100 mg lead/kg daily for nine weeks and four served as unexposed controls. After four weeks the difference between the number of correct responses on successive days was significantly more variable in the lead-dosed sheep. After nine weeks, the dosed animals achieved significantly fewer percent correct responses. The performance of three groups of five sheep was tested n a fixed interval schedule of reinforcement. The mean blood lead levels were 0.064, 0.171, and 0.302 ppm for the control, low, and high lead-fed groups. There was no significant difference between the number of reinforcements achieved by the three groups. There was no significant difference between the number of pedal responses of the control versus low lead and or control versus high lead. The difference in the mean number of pedal presses between the low lead (anti x = 132) and high lead (anti x = 112) was significant at P < 0.05. This difference was attributed to chance. 19 references, 4 figures,more » 5 tables.« less
34 citations
32 citations
TL;DR: The use of animal models for comparative studies of lead poisoning was discussed in this article, where animal models were used to compare the effects of different types of poisoning in humans and animals.
Abstract: (1973). The Use of Animal Models for Comparative Studies of Lead Poisoning. Clinical Toxicology: Vol. 6, No. 3, pp. 419-424.
30 citations
TL;DR: Acute strychrune Moxlcation is seldom observed even in the busiest clinical toxtcology sernces, Nevertheless, acute suychtune mtoxi&on is an interesting, dramatic, and even treatable form of poison if promptly dngnosed and d a rztional therapy u wed out.
Abstract: (1973). Pharmacokinetic Observations on a Case of Massive Strychnine Poisoning. Clinical Toxicology: Vol. 6, No. 4, pp. 533-540.
29 citations
28 citations
TL;DR: The information contained herein is offered to alert the medical profession to the occurrence and nature of lead poisoning in dogs, to establish the value of dogs as natural and experimental models for lead toxicity studies, and to indicate the usefulness of dogs and other pet animals as biologic barometers of environmental poisons dangerous to man.
Abstract: Pet animals share man's urban environment, dwelling even in his home, and are thus exposed to the same ecologic hazards. The study of lead poisoning and other toxicologic diseases in dogs and other pets may afford valuable insight into human environmental health problems. The purpose of this report is to summarize data gathered from a large number of accidentally lead-poisoned dogs studied at a large urban animal hospital (Angell Memorial Animal Hospital, Boston, Massachusetts), to review the published data of others on lead intoxication in accidentally and experimentally poisoned dogs, and to compare features of lead poisoning in dogs with those in man. The information contained herein is offered to alert the medical profession to the occurrence and nature of lead poisoning in dogs, to establish the value of dogs as natural and experimental models for lead toxicity studies, and to indicate the usefulness of dogs and other pet animals as biologic barometers of environmental poisons dangerous to man. 43 references.
22 citations
TL;DR: Toxicologic Findings in Six Fatalities Involving Methadone: Vol.
Abstract: (1973). Toxicologic Findings in Six Fatalities Involving Methadone. Clinical Toxicology: Vol. 6, No. 2, pp. 163-173.
21 citations
TL;DR: This study highlights the need to further delineate the incidence, clinical severity, sources, seasonal occurrence, and chemical results of affected and non-affected animals in cattle in Iowa.
Abstract: Lead poisoning has been increasingly recognized as a significant and major cause of bovine poisoning in Iowa during recent years [3, 4] Data from the Iowa Veterinary Diagnostic Laboratory for the years 1965 through 1971 indicate an increasing number of lead poisoning cases in cattle, with 1970 as the peak year From January, 1967, through June 30, 1971, 80 episodes of bovine lead poisoning have been confirmed by the Veterinary Diagnostic Laboratory Of this number, 28 were recognized in 1970 alone Lead poisoning is the single most common toxicosis in cattle in Iowa In order to further delineate the incidence, clinical severity, sources, seasonal occurrence, and chemical results of affected and non-affected animals, this study was undertaken
TL;DR: This work investigated the possibility that cannabidiol might cyclize to a THC upon smoking, and estimated the fractional delivery of cannABidiol in mainstream smoke.
Abstract: (1973). Toxicology of Marijuana: Conditions for Conversion of Cannabidioi to THC upon Smoking. Clinical Toxicology: Vol. 6, No. 2, pp. 211-216.
TL;DR: In Trial I, toxicosis was induced in 27 pigs by feeding 1000 ppM arsanilic acid in the ration, and the clinical syndrome was first characterized by transient diarrhea and incoordination, with posterior paresis and quadriplegia later.
Abstract: In Trial I, toxicosis was induced in 27 pigs by feeding 1000 ppM arsanilic acid in the ration. The clinical syndrome was first characterized by transient diarrhea and incoordination, with posterior paresis and quadriplegia later. Detectable histopathological changes were confined to the optic tracts, optic nerves, and peripheral nerves. Major lesions noted were necrosis of myelin-supporting cells and degeneration of myelin sheaths and axons. Maximum mean arsenic levels were present in liver, kidney, skeletal muscle, rib, and blood on or before day 13 of the experiment. Maximum mean arsenic levels in the nervous system were not attained until days 19 and 21. In Trial II, six pigs were fed 1000 ppM arsanilic acid in the ration for 19 days. Three days after the removal of dietary arsanilic acid, skeletal muscle, kidney, liver, and blood, respectively, retained 31, 34, 32, and 13 mean % of the tissue arsenic present at the time of drug withdrawal. Nervous tissue retained 100, 93, 57 mean % arsenic 3, 6, and 11 days post-withdrawal, respectively. In Trial III, six pigs were fed 1000 ppM arsanilic acid in the ration until they developed severe posterior paresis or quadriplegia. Four pigs had no clinical improvement and twomore » pigs developed a more severe paralysis after withdrawal of the drug. 12 references, 10 figures, 5 tables.« less
TL;DR: It is suggested that the study of known or suspected toxicologic diseases and the blood or tissue accumulation of various toxicants in urban pets, especially dogs and cats, might be of considerable value in determining the hazards of environmental lead and other toxins for urban man.
Abstract: Lead intoxication is common among young urban dogs. The age, seasonal, and slum occurrence is similar to that in children. The clinical signs, radiographic, hematologic, and urinary changes, and the tissue lesions are also comparable to those in children. Because of these similarities, the study of accidental and experimental lead poisoning in dogs may be of considerable comparative interest. It is suggested that the study of known or suspected toxicologic diseases and the blood or tissue accumulation of various toxicants in urban pets, especially dogs and cats, might be of considerable value in determining the hazards of environmental lead and other toxins for urban man.
TL;DR: In this paper, toxicology and adverse effects of Mineral Imbalance were studied in the context of clinical toxicology: Vol. 6, No. 3, pp. 459-485.
Abstract: (1973). Toxicology and Adverse Effects of Mineral Imbalance. Clinical Toxicology: Vol. 6, No. 3, pp. 459-485.
TL;DR: In this article, the effects of Yellow Phosphorus ingestion three fatal poisonings were investigated and the results showed that three poisonings can be classified into three categories: poisoning, poisoning, and poisoning.
Abstract: (1973). Yellow Phosphorus ingestion Three Fatal Poisonings. Clinical Toxicology: Vol. 6, No. 4, pp. 541-545.