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Showing papers in "Computers and Biomedical Research in 1991"


Journal ArticleDOI
TL;DR: Results obtained with a set of mammograms indicate that this method can improve the and reliability of systems for automated detection of breast tumors.

162 citations


Journal ArticleDOI
TL;DR: An 80386 PC-based system was designed to track automatically multiple, miniature radiopaque markers implanted in the heart wall, eliminating the need for tedious, time-consuming manual digitization of marker coordinates.

85 citations


Journal ArticleDOI
TL;DR: A frame-based system developed as an experimental approach to mapping between controlled clinical vocabularies is described, which aims to standardize terminology used for electronic hospital records and for knowledge bases for medical expert systems and indexing the medical literature.

76 citations


Journal ArticleDOI
TL;DR: In this paper, the authors developed a probabilistic reformulation of the Quick Medical Reference (QMR) system, which consists of a two-level, multiply connected, belief network.

66 citations


Journal ArticleDOI
TL;DR: VO2 was not changed because of the compensation from the calculated effects of changes in lung gas stores, and additional computations have shown that temperature correction can markedly affect calculated ventilatory volumes and N2 balance.

59 citations


Journal ArticleDOI
TL;DR: A computer program for minimizing differences between experimental groups with respect to such important parameters, based on a method described by Traves, is presented.

45 citations


Journal ArticleDOI
TL;DR: The design of a critiquing system, HyperCritic, that relies on automated medical records for its data input is described and it is shown how this domain-independent critiqueing structure can be used to facilitate knowledge acquisition and maintenance of the system.

45 citations


Journal ArticleDOI
TL;DR: Given a continuous variable S, which density functions on two subgroups omega + and omega - of a population omega are known, two strategies for classification in these groups are defined and mathematical formulas for the thresholds involved are given.

38 citations


Journal ArticleDOI
TL;DR: A query language is described, called TQuery, that was designed specifically to formulate database queries that are dependent on temporal and contextual relationships and express contextual constraints without the need to explicitly reference calendar dates.

27 citations


Journal ArticleDOI
TL;DR: A computer algorithm which removes the electrical pulse stimulus artifact from digitized electrophysiological recordings is described and the validity of the method is demonstrated from simultaneous recording of the same response with a minimal and maximal artifact.

27 citations


Journal ArticleDOI
TL;DR: A computer program, DLW, is described, that provides options to calculate doubly labeled water data in each of the accepted ways, including the "two-point" and "slope-intercept" methods.

Journal ArticleDOI
TL;DR: In this article, the authors describe the steps involved in converting existing highly iterative programs to a parallel form and present performance benchmarks comparing the sequential version of LINKMAP with the parallel version running on different parallel machines.

Journal ArticleDOI
TL;DR: This paper reviews algorithms currently in use to solve comparison problems in molecular biology and explains in detail and discussed in terms of the molecular biology problems it is most suited to solve.

Journal ArticleDOI
TL;DR: The presence of image- and anatomy-invariant features which facilitate automated, unconstrained identification, and localization of basic lower spine anatomy are explored.

Journal ArticleDOI
TL;DR: The development and use of the resulting tables of essentially exact discriminating powers (or ODDS) to do with comparisons of male given names are described here, to reduce the proportion of ambiguously linked pairs of records requiring labor intensive clerical resolution.

Journal ArticleDOI
TL;DR: Comparison of these reference equations with previously published equations derived for the same subjects, illustrates the advantages of having continuous equations throughout the age range of the data.

Journal ArticleDOI
TL;DR: Gain and phase parameters of sinusoidal eye movements between a stimulus and its response are computed after the recognition of eye movements and after removing corrective saccades from the transformed signal.

Journal ArticleDOI
TL;DR: A parallel version of a dynamic programming biological sequence comparison algorithm to study the potential applicability of using parallel computers for genetic sequence comparisons and a method of global interworker communication to reduce the total search time.

Journal ArticleDOI
TL;DR: The results suggest that there are more pathways of rapid propagation in the atria than those described and that a global anisotropy based on morphology and fiber direction is a more likely explanation than rapid propagation confined to a few specialized pathways.

Journal ArticleDOI
TL;DR: It is shown that the solution of the diffusion equation reported previously for the specific case where both the diffusion coefficient of a drug through the vehicle and skin-capillary clearance are very large is expressed as a limit.

Journal ArticleDOI
TL;DR: A causal model for diagnosing and explaining multiple disorders whose key elements are: physician-directed hypotheses generation, object-oriented knowledge representation, and novel explanation heuristics is proposed.

Journal ArticleDOI
TL;DR: Clinical application of VNA and OWA using a proposed noise variance estimation technique indicated that residual noise on the PR and ST segments can be further reduced in most of the cases and manifests that the new techniques have a potential advantage for improving the effectiveness of signal averaging as a fundamental method for surface detection of cardiac micropotentials.

Journal ArticleDOI
TL;DR: This paper presents empirically determined guidelines for specifying the number of features appropriate for multivariate classification studies for given sample sizes, based on the sample size data of 34 key papers on clinical body surface potential mapping (BSPM).

Journal ArticleDOI
TL;DR: The paper presents an experiment which was used in designing a heuristic which helps to determine numerical data from stylized literature excerpts in the context of knowledge acquisition for the QMR medical knowledge base.

Journal ArticleDOI
TL;DR: The study showed that several statistical approaches are possible for knowledge extraction from clinical data collected retrospectively, and utilized both statistical methods and artificial intelligence approaches in the estimation of missing values.

Journal ArticleDOI
TL;DR: This method is intended to detect the fetal HR from a weak FECG signal, and to supply us with an average FECG complex, and can be more generally applied to handle weak quasiperiodic sharp signals of any origin.

Journal ArticleDOI
TL;DR: The core of this architecture is described--a methodology for managing complex biomedical information in an extended relational framework that exploits a semantic data model to enhance relational databases with structuring and manipulation tools that take more domain information into account and provide the user with an appropriate level of abstraction.

Journal ArticleDOI
TL;DR: Through this study the proposed methodology was demonstrated to be a simple and efficient way to store, analyze, and compare basic neuroanatomical information.

Journal ArticleDOI
TL;DR: It was shown that the mean closing rate of single sodium channels in neonatal rat myocytes decreased with depolarization over a limited range of membrane potential, suggesting that the underlying closure mechanism(s) was voltage dependent.

Journal ArticleDOI
TL;DR: A Bayesian prediction program (Epidose) is presented which explicitly models PHT absorption and elimination kinetics in the non-steady state and demonstrates that the program can be used for accurate PHT concentration predictions in sick patients.